延胡索伍用白芷对延胡索乙素药动学的影响  

Effect of Rhizoma Corydalis Combined with Radix Augelica Dahurica on the Pharmacokinetics of Tetrahydropalmatine in Dogs

作　　者：洪战英[1] 乐健[2] 范国荣[1] 柴逸峰[1] 殷学平[1] 吴玉田[1] 

机构地区：[1]中国人民解放军第二军医大学药学院,上海市药物代谢产物研究重点实验室,上海200433 [2]上海市食品药品检验所,上海201203

出　　处：《中国药学杂志》2009年第8期620-623,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(30600815和30271603)

摘　　要：目的探索中药配伍对中药复方药效成分药动学的影响。方法采用反相高效液相色谱法测定延胡索乙素的血药浓度,非房室模型拟合药动学参数,统计学处理采用t检验法。结果延胡索提取物组和延胡索白芷提取物组的主要药动学参数:ρmax分别为(0.484±0.30)和(0.853±0.52)mg·L-1,AUC0-∞分别为(1.822±1.0)和(5.542±3.8)mg·h·L-1,tmax分别为(1.06±0.83)和(1.88±1.6)h,两组药动学参数的差异具有显著性统计学意义(P<0.05)。结论延胡索与白芷配伍对延胡索乙素的药动学特征有显著影响,提示该配伍可能是导致延胡索乙素的药动学特征变化的原因。OBJECTIVE To investigate the influence of Chinese herb prescription Yanhusuo-Baizhi on pharmacokinetic properties of tetrahydropalmatine（THP） in dogs. METHODS The concentrations of tetrahydropalmatine in dog plasma were determined by HPLC method. The pharmacokinetic parameters were calculated using non-compartmental model and t test was used for statistical analysis. RESULTS The mean ,Omax, AUC0-∞ and tmax of THP administrated with Yanhusuo-Baizhi extract were （0.853±0.52）mg.Ll, （5.542±3.8）mg·h ·L^-1 and （1.88±1.6）h, significantly higher （P〈0.05） than those administrated with Rhizoma Corydalis extract. CONCLUSION There was significant influence of Yanhusuo-Baizhi prescription on pharmacokinetics of THP in dogs, suggesting the compatibility in drug combination of Yanhusuo-Baizhi.

关 键 词：延胡索 延胡索乙素 复方配伍 药动学 白芷 

分 类 号：R969.1[医药卫生—药理学]