姜黄素固体分散体在大鼠体内的药动学研究  

Pharmacokinetics of Curcumin Solid Dispersion in Rats in vivo

作　　者：韩刚[1] 翟丽[1] 赵琳琳[1] 刘莉[1] 林庆辉[1] 毕瑞[1] 

机构地区：[1]华北煤炭医学院药学系,唐山市新药基础研究重点实验室,河北唐山063000

出　　处：《中国药学杂志》2009年第9期698-700,共3页Chinese Pharmaceutical Journal

摘　　要：目的以聚乙烯吡咯烷酮(PVP)、聚乙二醇(PEG)为载体,分别制备了姜黄素固体分散体。以姜黄素的普通片剂为参比制剂,研究固体分散体在大鼠体内的药动学过程。方法SD大鼠分别灌胃给予姜黄素固体分散体及姜黄素片剂,采用高效液相色谱法测定姜黄素的血药浓度,使用3P97软件计算药动学参数。结果姜黄素固体分散体在大鼠体内药动学过程符合单室模型,与姜黄素普通片剂相比ρmax,AUC显著增大,姜黄素-PVP固体分散体相对生物利用度为690%。结论姜黄素-PVP固体分散体能显著提高姜黄素在大鼠体内的生物利用度。OBJECTIVE To prepare curcumin solid dispersion with Polyvinylpyrrolidone （PVP） and Polyethylene glycol （PEG）, and to study the pharmacokinetics of curcumin solid dispersion in rats were used curcumin tablet as reference preparation. METHODS The rats were fed with curcumin solid dispersion and tablet. The curcumin concentration in whole blood was determined by HPLC. The date was processed by the 3P97. RESULTS The concentration-time curves of curcumin solid dispersion were diseribed with one-compartment model, The total areas under the plasma concentration-time curve AUC were larger than that of tablets and its bioavailability was 690%. CONCLUSION The curcumin solid dispersion could increase bioavailability in rats in vivo remarkably.

关 键 词：姜黄素 固体分散体 药动学 聚乙烯吡咯烷酮 聚乙二醇 

分 类 号：R969.1[医药卫生—药理学]