耐氨基糖苷类药物肺炎克雷伯菌的耐药谱分析  

Drug Resistance of Aminoglycoside-resistant Klebsiella pneumoniae

作　　者：黄海霞[1] 王金果[1] 陈坚[1] 余方友[1] 

机构地区：[1]温州医学院附属第一医院实验诊断中心,浙江温州325000

出　　处：《中华医院感染学杂志》2009年第9期1128-1130,共3页Chinese Journal of Nosocomiology

摘　　要：目的调查耐氨基糖苷类药物肺炎克雷伯菌的耐药特点。方法收集2006年1月-2007年9月从临床分离的肺炎克雷伯菌共64株;采用全自动微生物分析仪进行菌种鉴定,用K-B法进行药敏试验;其中64株耐庆大霉素肺炎克雷伯菌用头孢噻肟、头孢噻肟/克拉维酸和头孢他啶、头孢头啶/克拉维酸双纸片扩散法检对肺炎克雷伯菌进行超广谱β-内酰胺酶检测。结果64株耐庆大霉素的菌株对环丙沙星、左氧氟沙星、头孢西丁、四环素头、复方新诺明、头孢他啶、头孢噻肟和亚胺培南的耐药率分别为7.5%、29.7%、39.1%、85.9%、76.6%、67.2%、73.4%和0;47株经双纸片扩散法确定为ESBLs阳性率为73.4%;所有耐庆大霉素株均为多药耐药株。结论耐氨基糖苷类药物的肺炎克雷伯菌呈多药耐药性。OBJECTIVE To investigate the antimicrobial-resistant profile of aminoglycosides-resistant Klebsiella pneumoniae isolated from Wenzhou. METHODS Between Jan 2006 and Sep 2007, non-replicate clinical isolates of K. pneumoniae were consecutively collected from inpatients in a teaching hospital in Wenzhou,China. Antibiotic susceptibility test was determined by the disc diffusion method recommended by CLSI. Sixty-four gentamicin- resistant isolates were investigated for the presence of ESBLs by the CLSI-recommended confirmatory tests. RESULTS Of the 64 gentamicin-resistant isolates, the resistant rates to ciprofloxacin, levofloxacin cefoxitin, tetracycline, trimethoprim/sulfamethoxazole, ceftazidime and cefotaxime were 7.5 %, 29.7 %, 39.1%, 85.9 %, 76.6%,67.2%, and 73. 4%, respectively. All isolates were susceptible to imipenem. 73. 4% of gentamicin- resistant isolates produced ESBLs. CONCLUSIONS Gentamicin-resistant K. pneumoniae is multi-resistant to antibiotics.

关 键 词：肺炎克雷伯菌 氨基糖苷类药物 耐药性 

分 类 号：R978.12[医药卫生—药品]