重症监护病房下呼吸道医院感染病原菌分布及药敏结果分析  

Pathogens from Lower Respiratory Tract:Result and Analysis of Their Distribution and Antibiotic Resistance

作　　者：李素晓[1] 张立志[1] 张玉英[1] 刘甲俊[1] 张莉娟[1] 

机构地区：[1]河北省人民医院院感科,河北石家庄050051

出　　处：《中华医院感染学杂志》2009年第9期1155-1157,共3页Chinese Journal of Nosocomiology

摘　　要：目的监测下呼吸道医院感染病原菌的菌群分布和耐药谱,指导临床合理应用抗菌药物。方法对2005年全年及2006年上半年重症监护病房(ICU)下呼吸道医院感染患者病原菌的菌群分布、耐药性进行分析。结果革兰阴性杆菌是引发下呼吸道医院感染的主要病原菌,占89.3%,其中以铜绿假单胞菌、克雷伯菌属占优势,分别占47.6%、21.2%;革兰阳性球菌中主要为金黄色葡萄球菌,占6.2%,MRSA菌株有增加趋势;真菌占5.8%,所有病原菌对各种抗菌药物的耐药率均很高。结论ICU下呼吸道医院感染病原菌的菌群分布和耐药性易发生变化,临床医师必须密切关注病原菌分布及耐药性变迁,合理应用抗菌药物。OBJECTIVE To monitor the distrubution and the change in drug resistance of pathogenic bacteria from lower respiratory tract in patients with comprehensive intensive care to use the antibiotic properly in the clinics. METHODS All lower respiratory infection cases admired to the ICU in 2005-2006 were reviewed, and the distribution of pathogenic bactieria and their drug resistance profile were analyzed. RESULTS 89.3% pathogenic bacteria were Gram-negative ones, among them Pseudomonas aeruginosa （47.6%） and Klebsiella pneumoniae （21.2%） were prevailed. Staphylococcus aureus （6.2%） was the most prominent Gram-positive bacteria, MRSA showed increasing trend. Fungi accounted for 5.8%. All pathogenic bacteria showed high resistance to the antibiotics. CONCLUSIONS The pathogenic bacteria and their resistance to the antibiotics are highly changed at ICU. Intensive observations from the clinicians are recommanded so as to make the antibiotics effective.

关 键 词：重症监护病房 下呼吸道感染 医院感染 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]