人参二醇皂苷对急性血瘀模型大鼠血液流变性及PGF1a、TXB2的影响  

Effects of Panaxdiols Saponin on Hemorheological Parameters and PGF_(1a),TXB_2 in Rat Model of Acute Blood Stasis

作　　者：王秋静[1] 刘芬[1] 刘洁[1] 赵雪俭[1] 路萌萌[2] 

机构地区：[1]吉林大学白求恩医学院,吉林长春130021 [2]吉林大学口腔医学专业2007级,吉林长春130021

出　　处：《中国实验方剂学杂志》2009年第5期52-54,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科技厅自然科学基金资助项目(20030501)

摘　　要：目的:观察人参二醇皂苷(Panaxdiols Saponin,PDS)对急性血瘀模型大鼠血液流变性及PGF1a和TXB2的影响。方法:Wistar大鼠60只,随机分为6组:对照组;模型组;阳性对照组;PDS5,10,20mg·kg-13个剂量组。采用sc肾上腺素加冰水冷浴法制备大鼠急性血瘀模型,舌下iv给药,观察PDS对急性血瘀模型大鼠血液流变性及PGF1a和TXB2的影响。结果:PDS能降低急性血瘀模型大鼠全血黏度,增加心、肺组织中PGF1a含量,减少TXB2含量。结论:PDS对急性血瘀模型大鼠血液流变性异常有明显改善作用,能纠正PGF1a与TXB2之间的平衡失调。Objective： To investigate the effects of Panaxdiols Saponin （PDS）on hemorheology and PGF1a, TXB2 in rat model of acute blood stasis. Methods： Sixty rats were divided at random into six groups：normal control, model control, positive control, 5 mg· kg^- 1 PDS, 10 mg· kg^- 1 PDS and 20 mg· kg^- 1 PDS groups. The blood stasis model was made by adrenaline administration and coldness stimulation. The effects of PDS（iv. ） on hemorheological parameters and PGF1a, TXB2 in rat model were observed. Results： PDS can decrease the whole blood viscosity and TXB2 in heart and lung, increase PGF1a in heart and lung. Conclusions： PDS improves significantly abnormal changes of hemorheological parameters in rat model of acute blood stasis. PDS can adjust the balance between PGF1a and TXB2 .

关 键 词：人参二醇皂苷 急性血瘀模型 血液流变学 前列腺素F1a 血栓素B2 

分 类 号：R285.5[医药卫生—中药学]