锑对小鼠肝线粒体抗氧化酶和ATP酶活性影响的研究  

Effect of Antimony Trioxide on Antioxidative Enzyme and ATPase Activity of Mitochondria in Liver of Mice

作　　者：王安[1] 安飞云[1] 高泽宣[1] 王夷平[1] 

机构地区：[1]湖南医科大学环境医学研究室

出　　处：《中国公共卫生学报》1998年第2期86-87,共2页

摘　　要：采用亚急性中毒的实验模型，观察三氧化二锑对小鼠肝线粒体抗氧化酶和ＡＴＰ酶活性的影响。实验结果表明：每天腹腔注射４０ｍｇ／ｋｇ三氧化二锑，共２８天，肝线粒体超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的活性明显低于对照组（Ｐ＜０．０５）；与对照组相比，肝线粒体Ｎａ＋Ｋ＋－ＡＴＰ酶及Ｃａ－ＡＴＰ酶活性分别下降３３．６％和１２．５％。说明锑引起肝损害的机理与其损伤肝线粒体的抗氧化能力和抑制肝线粒体Ｎａ＋Ｋ＋－ＡＴＰ酶及Ｃａ－ＡＴＰ酶活性有关。Using a subacute toxic experimental model,the effect of antimony trioxide on Antioxidative Enzyme and ATPase activity of mitochondria in the mice was observed.After injected (i.p) with antimony trioxide 40mg/kg daily for 28 days,the results revealed that the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) of liver mitochondria in the antimony trioxide group was lower than the control group (P<005),compared with control group,the activity of Na +K +ATPase and Ca ATPase in liver mitochondria was respectively decreased 336% and 12 5%. The results shows that the mechanisms of antimony trioxide induced hepatic damage wag relation with the injury of Antioxidative ability and inhibition of ATPase activity in liver mitochondria.

关 键 词：三氧化二锑 肝线粒体 抗氧化酶 ATP酶 

分 类 号：R995[医药卫生—毒理学]