黄芪多糖对环磷酰胺所致免疫低下小鼠作用的实验研究  

Effectiveness of astragalus polsaccharides against lowered immunity due to cyclophamide in mice

作　　者：潘惠娟[1] 宋涛[1] 

机构地区：[1]武警总医院病理科,军事医学科学院六所

出　　处：《武警医学》1998年第2期67-69,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：为探讨黄芪多糖对环磷酰胺引起副作用的影响，我们应用溶血空斑形成（ＰＦＣ）实验观察了黄芪多糖（ＡＰＳ）２５０ｍｇ，５００ｍｇ，１０００ｍｇ／ｋｇ口服对环磷酰胺（ＣＹ）５０ｍｇ／ｋｇ皮下注射所致实验小鼠免疫低下的作用，结果表明黄芪多糖可拮抗环磷酰胺所致免疫低下，分别使溶血空斑计数据高了３５４．６％，１８６．６％，１３８．６％，提示黄芪多糖对环磷酰胺所致体液免疫障碍有明显改善作用。To find the optimal dosage of astragalus polysaccharides in regulation of immunity , the effectiveness of astragalus polysaccharides against lowered immune function due to administration of cyclophosphamide was observed in five groups of mice . The as- tragalus polysacccharides were given orally in doses of 250 mg/kg , 500 mg/kg and l000 mg/kg , while cyclophosphamide 50 mg/kg was given by hypodermic injection . The results showed that plaque forming cells were increased 354.6% , 186.6% and 138.6% , respec- tively , suggesting that the astragalus polysaccharides can antagonize the action of cyclophosphamidecausing low immunity . It is conclud- ed that the astragalus polysaccharides can avert the cyclophosphamide - induced humoral immunity decline side effect , and the optimal dose is 250 mg/kg .

关 键 词：小鼠 免疫功能 黄芪多糖 环磷酰胺中毒 溶血空斑 

分 类 号：R977.9[医药卫生—药品] R965.2[医药卫生—药学]