P6A和RGD杂交肽的构象研究  

Studies on the Conformations of P6A and RGD Containing Peptides

作　　者：赵明[1] 张亮仁[1] 彭师奇[1] 周琴璐[2] 李强[2] 赵文忠[2] 

机构地区：[1]北京医科大学药物化学系 [2]北京市体育科学研究所

出　　处：《中国药物化学杂志》1998年第1期31-39,共9页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金

摘　　要：用Ｂｉｏｓｙｍ公司的Ｄｉｓｃｏｖｅｒ程序计算了Ｐ６ＡＲＧＤＳ，Ｐ６ＡＲＧＤＶ，Ｐ６ＡＲＧＤＦ，ＱＰ６ＡＲＧＤＳ，ＱＰ６ＡＲＧＤＶ和ＱＰ６ＡＲＧＤＦ６种九肽在真空中、水中和正辛醇中的优势构象对应的能量．发现优势构象的总能量水平能反映这些九肽与ＧＰⅡｂ／Ⅲａ受体结合的情况，从而为以ＧＰⅡｂ／Ⅲａ受体为靶点的含ＲＧＤ多肽药物设计提供帮助．The conformation energies of P6ARGDS,P6ARGDV,P6ARGDF,QP6ARGDS,QP6ARGDV and QP6ARGDF at vaccum,in water and in octanol were calculated by use of the Discover program (Biosym).It was found that the total energies of the stable conformations were useful for deducing the binding states of these peptides and GP Ⅱb/Ⅲa receptor,and provided helps for the design of the drugs containing RGD targeting on GP Ⅱb/Ⅲa.

关 键 词：RGD P6A 构象 抗血栓 杂交肽 

分 类 号：Q516[生物学—生物化学]