冠脉介入治疗对缺血性心肌病患者脑钠肽水平的影响  

Influence of Percutaneous Coronary Intervention on Plasma Brain Natriuretic Peptide Level in Patients with Ischemic Cardiomyopathy

作　　者：罗海波[1] 袁旭明[2] 何昕[2] 刘景艳[2] 刘智勇[2] 

机构地区：[1]湖南省浏阳市人民医院老干科,湖南浏阳410300 [2]湖南省浏阳市人民医院心内科,湖南浏阳410300

出　　处：《医学临床研究》2009年第4期635-637,共3页Journal of Clinical Research

摘　　要：【目的】观察缺血性心脏病患者采用经皮冠状动脉介入治疗（PCI）对脑钠肽（BNP）水平的影响。【方法】选择心功能Ⅱ～Ⅲ级缺血性心肌病患者150例，随机分为非PCI组75例和PCI组75例。非PCI组，应用常规抗心衰药物治疗。PCI在常规抗心衰治疗基础上行PCI,然后在半年复查，比较治疗前后血浆浓度。【结果】治疗前非PCI组和PCI组的BNP的浓度（pg／mL）分别为（284．75±35．34）、（297．46±36．89）；（P=NS）。而经治疗后非PCI组和PCI组的BNP的浓度分别为（125．87±18．65、83．55±20．12；P〈0．01）。介入治疗组治疗心衰疗效优于非PCI组，血浆BNP下降率大于非PCI组。【结论】改善缺血性心脏病患者的心功能，能显著降低血浆BNP的浓度。[Objective] To observe plasma brain nutriuretic peptide（BNP） level of patients with ischemic cardio- myopathy（iCM） after percutaneous coronary intervention（PCI）. [Methods]A total of 150 ICM patients with Ⅱ-Ⅲ New York Heart Assoeiation（NYHA） functional classification were chosen and randomly divided into the non-PCI group（n=75） and PCI group（ n = 75）. The patients in the non-PCI group were treated with routine anti-heart failure drugs,and the patients in the latter group were treated by PCI on the basis of above regular treatments. All the pa tients were detected the concentrations of BNP before and after treatment. [Results]Before treatment, plasma BNP levels of the non-PCI group and PCI group were （284.75±35.34）pg/mL and （297.46±36.89）pg/mL, respectively （ P=NS）. After treatments, plasma BNP levels of the non-PCI group and PCI group were （125.87± 18.65） pg/mL and （83.55±20.12） pg/mL, respectively （P〈0.01）. In PCI group,the treatment effect of heart failure was more excellent, the descendent rate of BNP was higher than that in the non-PCI group. [Conclusion] PCI can obviously de- crease plasma content of BNP and improve cardiac function in ICM patients.

关 键 词：心肌缺血/治疗 利钠肽 脑 冠状动脉疾病/治疗 

分 类 号：R542.2[医药卫生—心血管疾病]