针灸对帕金森病大鼠模型脑内单胺类递质含量的影响  

EFFECTS OF ACUPUNCTURE AND MOXIBUSTION ON THE CONTENTS OF MONO AMINOTRANSMITTERS IN BRAIN OF RAT MODEL WITH PAKINSON'S DISEASE

作　　者：何崇[1] 王玲玲[1] 董洪涛[1] 汪君梅[1] 马骋[1] 

机构地区：[1]南京中医药大学,南京210029

出　　处：《中国中医药科技》1998年第2期65-67,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：本研究初步观察了大鼠帕金森病模型纹状体内三种单胺类递质多巴胺(DA)、去甲肾上腺素(NA)、5-羟色胺(5-HT)针灸治疗前后的变化情况,在此基础上,为了摸索针灸的临床治疗规律,本组资料选择了不同选穴和不同针灸方法进行分组,观察这些针灸刺激因素对单胺类递质的影响。结果表明,针灸后大鼠纹状体内DA、NA、5-HT明显上升,此外,从选穴的角度看,头部选穴明显优于四肢,头部选穴各级差别虽无统计学意义,但组间差别似乎反应针刺方法作用较平均,艾灸和电刺激方法对儿茶酚胺类递质作用更明显。In this research, the changes of three monoaminotransmitters ie. dopamine(DA) , noradreanini(NA) and 5 - serotion(5 - HT), in striatum corpus of rat model with Parkinson's disease induced by 6 - hy-droxydopamine (6- OHDA) before and after acupuncture and moxibustion therapy were compared. Also the different effects of various acupuncture stimulation factors were observed. The results shown that the level of three transmitters was significantly elevated after the treatment of Acu. & Mox. the effect of selecting head points was better than siguan group selecting limb points among the treatment groups. All these suggested that Acu. & MOx. is a good way to raise monoaminotransmitters in rat brain, which is conducive to the recovery of Parkinson's disease.

关 键 词：针灸疗法 帕金森病 动物模型 单胺类递质 

分 类 号：R246.6[医药卫生—针灸推拿学] R277.725[医药卫生—中医临床基础]