口服康泉预防中度致吐化疗药所致呕吐30例  

CLINICAL OBSERVATION ON THE PROPHYLACTIC EFFECT OF ORAL GRANISETRON IN MANAGEMENT OF VOMITING INDUCED BY MODERATE EMETIC CHEMOTHERAPY

作　　者：张频[1] 冯奉仪[1] 黄镜[1] 张湘茹[1] 李青[1] 张弘纲[1] 周立强[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院内科

出　　处：《中国新药杂志》1998年第2期113-116,共4页Chinese Journal of New Drugs

摘　　要：目的：３０例接受顺铂或阿霉素加环磷酰胺联合化疗病人，采用随机、交叉、自身对照方法，观察口服康泉的止吐作用，并同时与静脉康泉比较，观察两者的疗效和毒性。方法：口服康泉１ｍｇ，ｂｉｄ，静脉康泉３ｍｇ，静脉冲入，ｑｄ。结果：对顺铂所致呕吐，口服康泉总有效率为７８６％，完全控制率５７１％；静脉康泉总有效率及完全控制率均为６４３％。对非顺铂所致呕吐，口服及静脉康泉的有效率均为９３８％，完全控制率分别为８７５％、８１２％。结论：口服康泉能有效预防中度致吐化疗药所致呕吐，其疗效与静脉康泉相似，且口服安全，有效，方便，更适合门诊病人。OBJECTIVE:Thirty patients were enrolled in the randomized, crossover, selfcontrol study for comparison the efficacy and tolerability of oral and injection granisetron.METHODS:Oral granisetron is in a twice daily dose of 1 mg; intravenous granisetron is in a once daily dose of 3 mg. RESULTS:Total effective rate and complete control rate of oral dose in control vomiting induced by cisplatin were 78.6% and 57.1% respectively, and those of intravenous dose were 64.3% and 64.3% respectively. Total effective rate and complete control rate of oral dose in control vomiting induced by noncisplatin drugs were 93.8% and 87.5% respectively, and those of intravenous dose were 93.8% and 81.2% respectively. CONCLUSION:Oral granisetron is as effective as intravenous granisetron in prevention of vomiting induced by moderate emetic chemotherapy. It is a safe, effective and convenient dosage for management of emesis especially suitable for outpatients.

关 键 词：口服康泉 控制 防治 呕吐 化疗药物 

分 类 号：R975.4[医药卫生—药品]