心脉龙对慢性肺心病患者血液动力学变化的研究  

STUDY ON EFFECT OF XINMAILONG ON HEMODYNAMIC CHANGES IN PATIENTS WITH CHRONIC COR PULMONALE

作　　者：李兴文[1] 戴路明[1] 黄维丽[1] 张济建[1] 杨玉萍[1] 张效予[1] 李毓敏[1] 

机构地区：[1]昆明医学院第一附属医院呼吸内科

出　　处：《中国新药杂志》1998年第2期137-141,共5页Chinese Journal of New Drugs

基　　金：云南省科委应用基础研究基金

摘　　要：目的：应用心脉龙注射夜治疗肺心病患者，观察其对血液动力学效应，评价其临床疗效。方法：３０例肺心病代偿期伴右心室单纯性舒张功能不全患者应用心脉龙注射液（Ａ组），另６０例肺心病心衰Ⅱ°患者，随机分为３０例心脉龙注射液组（Ｂ组）及３０例对照组（地高辛＋酚妥拉明，Ｃ组）。采用ＳＰＥＣＴ心血池动态显像术，测右心室收缩功能及舒张功能，对比观察药物对肺心病患者的血液动力学效应，同时观察心率、血压、肝肾功能。结果：Ａ组治疗后舒张功能显著改善（Ｐ＜００５或Ｐ＜００１）；Ｂ组治疗后收缩、舒张功能均有显著改善（Ｐ＜００５或Ｐ＜００１）。Ｂ与Ｃ组比较治疗后收缩、舒张功能相应值均有显著差异（Ｐ＜００５或Ｐ＜００１）。结论：心脉龙对肺心病心衰有极好的血液动力学效应，对心率、血压、肝肾功能无影响，该药有临床应用价值。OBJECTIVE:Patients with cor pulmonale were treated with Xinmailong injections to observe their hemodynamic changes in order to evaluate its clinical efficacy. METHODS: Patients enrolled into the study were equally divided into three groups:group A:30 patients with right ventricular diastolic disfunction were treated with Xinmailong. Group B and C: Each consisted of 30 patients with IIphase right heart failure. Group B were treated with Xinmailong and group C were treated with digoxin+regitin. Before and after treatment, the following parameters were measured by SPECT blood pool ventriculography: RVEF(right ventricular ejection fraction); 1/3 EF(1/3 ejection fraction); 1/3ER (1/3 ejection rate); PFR(peek filling rate); 1/3 FR(1/3 filling rate); and 1/3FF (1/3 filling fraction). RESULTS:After treatment, diastolic function were significantly improved in group A patients and also markedly improved in group B patients. The systolic and diastolic function were markedly improved in group B patients in comparison with those in group C patients. CONCLUSION:Xinmailong is a promising drug for treatment of cor pulmonale with heart failure on the basis of hemodynamic changes and without effects on heart rate, blood pressure and liver functions.

关 键 词：心脉龙 肺心病 血液动力学 

分 类 号：R541.505[医药卫生—心血管疾病]