痰瘀同治法防治大鼠急性心肌缺血的实验研究  

Experimental Study of Protective Effect of Synchronically Treating Phlegm and Blood Stasis on Acute Myocardial Ischemia in Rats

作　　者：朱伟[1] 周洁[1] 李志[2] 

机构地区：[1]泸州医学院药学院,四川泸州646000 [2]泸州医学院附属中医院,四川泸州646000

出　　处：《辽宁中医药大学学报》2009年第5期189-191,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察痰瘀同治法对大鼠急性心肌缺血的防治及作用机制,为痰瘀同治法防治胸痹提供实验依据。方法:采用舌下静脉注射垂体后叶素0.7u/kg建立大鼠急性心肌缺血模型,观察缺血心肌的T波变化情况,并检测大鼠血清丙二醛(MDA)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)的水平。结果:与化痰法、活血化瘀法相比,痰瘀同治法能明显增强心肌缺血大鼠血清中的SOD活性,显著降低MDA、LDH水平,改善大鼠急性心肌缺血状况。结论:痰瘀同治法应当成为现代防治冠心病(胸痹)的重要法则和提高临床疗效的主要途径之一。Objective：By observing an effect of synchronically treating phlegm and blood stasis on preventing and treating the acute myocardial ischemia in rats,provide laboratory evidence for the theory of synchronically treating phlegm and blood stasis to prevent and treat the thoracic obstruction. Methods：To inject 0.7u/kg pituitrin by sublingual intravenous to establish the model of acute myocardial ischemia in rats,then,the researchers instantly record the variations in T wave of each rat,and observe the level of malondialdehyed（MDA）,lactate dehydrogenase（LDH） and superoxide dismutase（SOD） in the serum of rats. Results：To compare two methods with dissipating phlegm and promoting blood stasis,the method with synchronically treating phlegm and blood stasis could apparently reinforce SOD activity,reduce the level of MDA and LDH in the serum of the acute myocardial ischemia in rats,improve the condition with acute myocardial ischemia in rats. Conclusion：The method of synchronically treating phlegm and blood stasis can improve acute myocardial ischemia,and inhibit the lipid peroxdation,the effect on controlling the thoracic obstruction with the method of synchronically treating phlegm and blood stasis has apparent advantages over the single method of dissipating phlegm or promoting blood stasis,it＇s an important way of preventing and curing coronary heart disease（thoracic obstruction）.

关 键 词：痰瘀同治 胸痹 急性心肌缺血 

分 类 号：R242[医药卫生—中医临床基础]