SPF种鸡接种REV弱毒疫苗后安全性及母源抗体对SPF雏鸡的保护作用  

Safty of SPF Parent Breeders Inoculated with an attenuated Reticuloendotheliosis Virus and the Protection of Maternal Antibody to Chicks

作　　者：吴玉宝[1] 朱美真[1] 崔治中[1] 

机构地区：[1]山东农业大学动物科技学院,山东泰安271018

出　　处：《西南农业学报》2009年第2期497-501,共5页Southwest China Journal of Agricultural Sciences

基　　金：农业部"十一五"支撑计划项目(2006BAD06A08)

摘　　要：18周龄SPF种鸡在用网状内皮增生病病毒（REV）弱毒疫苗免疫接种后，均在11d内产生REV特异性抗体。种鸡在免疫后1～15d内均未检出病毒血症。在开产后在5个月的产蛋期内，来自免疫种鸡的雏鸡100％REV母源抗体阳性。对3日龄雏鸡的攻毒试验表明，相对于无母源抗体的SPF鸡，REV母源抗体能有效地预防或减弱经接种REV低代毒造成的生长迟缓、中枢免疫器官萎缩及其对NDV和AIV灭活疫苗免疫后抗体反应的抑制作用。SPF breeders of 18-week-old were vaccinated with attenuated vaccine of reticuloendotheliosis virus, all chickens became REV-antibody positive lld after vaccination. There was no viremia diteccted in 1-15 days after vaccination. And no REV was detected in 35 embryos collected in the early days of laying. All chick from vaccinated breeders were REV-matemal antibody positive in five months after vaccination. Restults in challenging studies at 3-day-old birds indicated that REV-matemal antibodies could effectively protect chicks from REV infection and prevent growth retardation, atrophy of central immune organs and immunosuppression on antibody responses to NDV and AIV vac- cination induced by REV infection.

关 键 词：网状内皮增生病病毒 安全性 母源抗体 

分 类 号：S851.347.2[农业科学—预防兽医学]