银杏叶提取物对实验性心肌梗死大鼠心脏促血管生成作用的观察  

The Stimulate Angiogenesis Effect of EGb on the Hearts of Myocardial Infarction Rats

作　　者：范冀湘[1] 高绍芳[2] 贾旭[3] 

机构地区：[1]岳阳职业技术学院,湖南岳阳414000 [2]河北医科大学 [3]石家庄卫生学校,河北石家庄050200

出　　处：《中医药导报》2009年第4期4-6,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨银杏叶提取物对实验性心肌梗死大鼠冠状动脉侧支血管生成的影响及其机制。方法:将30只实验性大鼠随机分成银杏叶提取物组(A组),肝素对照组(B组),模型组(C组),建立心肌缺血模型,15d后检测缺血梗死面积、缺血梗死边缘区VEGF、bFGF的表达量。结果:A组缺血梗死面积小于B组、C组,缺血梗死边缘区VEGF、bFGF的表达量增加。结论:银杏叶提取物能促进心肌缺血大鼠冠状动脉侧支血管的生成,对缺血心肌具有保护作用。Objective： To stimulate angiogenes effect and mechanism of Ginkgo biloba extract on coronary collateral developments in the hearts of experimental myocardial infarction rats were studied. Methods： 30 myocardial infarction rats were randomly divided into 3 groups, lO rats in group A were treated with Ginkgo biloba extract, l0 rats in group B were treated with heparin, and 10 rats in group C were treated with 0.9% normal saline as control.Infarct area, the contents of VEGF, Bfgf in the edge of infarct section were measured after 6 weeks treating. Results： Infarct area in group A was obviously less than that in groups C, the contents of VEGF, bFGF in the edge of infarct section in group were significantly increased compared with those in group C. Conclusions： Ginkgo biloba extract can stimulate angiogenesis of the collateral branch of coronary in ischemic myocardium of rats and show good a protection on myocardial ischemia.

关 键 词：银杏叶提取物 侧支循环 血管生成 心肌梗死 

分 类 号：R285.5[医药卫生—中药学]