反社会人格障碍患者的脑灰质结构研究  

Morphological changes of cerebral gray matter in patients with antisocial personality disorder

作　　者：廖坚[1] 罗贤明[1] 王维[1] 吴大兴[2] 柯铭[3] 吕云霄[3] 周建松[2] 

机构地区：[1]中南大学湘雅三医院放射科,长沙410013 [2]湘雅二医院精神卫生研究所 [3]国防科技大学机电工程与自动化学院自动控制系

出　　处：《中华精神科杂志》2009年第2期89-91,共3页Chinese Journal of Psychiatry

基　　金：基金项目：“十一五”国家科技支撑计划资助项目（2007BA117803）

摘　　要：目的研究反社会人格障碍（APD）患者与正常人大脑灰质结构的异同。方法对17例APD患者（APD组）和19名与APD组的年龄、性别、智商及文化程度匹配的正常对照者（正常对照组）进行脑部T1加权像及3维结构像扫描，并使用基于体素的形态学分析法进行数据分析。结果APD组左额上回（BA8）、右楔前叶、左眶额回、双侧额中回、右额内侧回、右侧顶下小叶、左梭状回、双侧颞上回及双侧小脑的灰质密度低于正常对照组，而左额上回（BA38）及左海马旁回的密度高于正常对照组（P〈0．005）。结论APD患者存在脑结构的异常，主要包括前额叶、眶额回、楔前叶、颞叶及双侧小脑。Objective To investigate the morphological changes of cerebral gray matter in people with antisocial personality disorder in comparison to normal control. Methods Voxel based morphometry in conjunction with statistical parametric mapping was applied to the structural magnetic resonance images of 17 persons with antisocial personality disorder and 19 normal controls. Results Compared with the controls, the cerebral gray matter concentrations were significantly decreased in the left superior frontal cortex, bilateral middle frontal cortex, left orbitofrontal cortex, bilateral cerebellum, right inferior parietal lobule and bilateral superior temporal cortex of people with antisocial personality. Conclusion The results suggest the gray matter of the prefrontal cortex, orbitofrontal cortex, precuneus and cerebellum is lost in some degree in people with antisocial personality disorder patients.

关 键 词：反社会性人格障碍 磁共振成像 端脑 

分 类 号：R686[医药卫生—骨科学]