趋化细胞因子ENA-78在子宫腺肌病中的表达  

Expression of chemokine epithelial neutrophil-activating peptide-78 in adenomyosis

作　　者：徐红[1] 陈煜岊[1,2] 何中慧[1] 梁秀就[3] 徐文生[1] 蒙玉刚[1] 

机构地区：[1]广西医科大学第一附属医院妇科,广西南宁530021 [2]柳州市人民医院 [3]广西医科大学第一附属医院病理科,广西南宁530021

出　　处：《中国妇幼保健》2009年第13期1846-1848,共3页Maternal and Child Health Care of China

基　　金：广西科学基金资助项目(桂科自No.0542082);广西医疗卫生科研课题(Z2005049)

摘　　要：目的:探讨趋化细胞因子(ENA-78)在子宫腺肌病组织中的表达及其与子宫腺肌病发生、发展的关系。方法:收集27例子宫腺肌病患者的异位内膜及在位内膜组织和18例子宫肌瘤在位子宫内膜组织(对照组),分别测定ENA-78的表达。结果:①ENA-78阳性染色定位于腺体细胞胞浆内;②子宫腺肌病患者的在位内膜及异位内膜ENA-78的表达高于对照组(P<0.05);③不同月经周期中子宫腺肌病患者的在位内膜与异位内膜组织中ENA-78的表达无统计学意义(P>0.05)。结论:ENA-78在子宫腺肌病的异位内膜及在位内膜组织中表达增强,提示ENA-78在子宫腺肌病发生、发展中有一定意义。Objective ： To explore the expression of epithelial neutrophil - activating peptide - 78 （ ENA - 78 ） in adenomyosis and the relationship between ENA - 78 and the mechanism of ademomyosis. Methods ： The expression of ENA - 78 in the ectopic and eutopic endometria of 27 patients with adenomyosis and in the eutopic endometria of 18 patients with hysteromyoma were detected by immunohistochemistry. Results ： ①ENA - 78 located in the cytoplasma of epithelial glands. ②The expression levels of ENA - 78 in the ectopic and eutopic endometria in adenomyosis group were significantly higher than those in control group （ P 〈 0. 05 ） . ③The expression of ENA - 78 in the ectopic and eutopic endometria of adenomyosis had no difference between secretory phase and proliferative phase （ P 〉 0. 05 ） . Conclusion ： The expression of ENA-78 in the ectopic and eutopic endometria of adenomyosis increases, which suggests that ENA-78 may play a role in pathophysiology and progression of adenomyosis.

关 键 词：趋化细胞因子 ENA-78 子宫腺肌病 免疫组织化学 

分 类 号：R711.7[医药卫生—妇产科学]