静脉注射钆类对比剂对乳腺正常腺体及肿瘤组织MR扩散加权成像的影响  

The effect of intravenous administration of gadolinium contrast medium on diffusion-weighted MR of breast

作　　者：王岳[1] 武春雪[1] 杨学东[1] 王霄英[1] 

机构地区：[1]北京大学第一医院医学影像科,100034

出　　处：《中华放射学杂志》2009年第5期476-479,共4页Chinese Journal of Radiology

摘　　要：目的探讨乳腺MRDWI质量及正常腺体与癌组织的ADC值是否受到钆类对比剂增强扫描的影响。方法对25例已经针吸穿刺或粗针活检病理证实为乳腺癌的患者在静脉注射Gd-DTPA前、后行DWI扫描，将ROI分别置于癌灶及正常腺体，应用配对t检验及非参数检验比较b值=0及1000s／mm^2时增强前后图像中癌灶和正常腺体的信噪比（SNR）、对比噪声比（CNR）及ADC值的变化。结果增强前、后癌灶的SNR（34．56±11．34和33．60±14．34）与正常腺体的SNR（9．88±3．16和10．42±4．18）以及图像CNR（24．16±9．05和22．26±10．05）的差异无统计学意义（P癌灶SNR=0．70，P正常腺体SNR=0．11；PCNR=0．17）；增强前后癌灶的ADC值分别为（0．96±0．13）×10^-3和（0．95±0．14）×10^-3mm^2／s，正常腺体分别为（1．90±0．47）×10^-3和（1．91±0．61）×10^-3mm^2／s，两者在增强后ADC值与其增强前差异均无统计学意义（P=0．20和0．97）。结论乳腺癌组织和正常腺体DWI的质量及ADC测量值不会受到Gd—DTPA的影响，故在乳腺MR扫描中，DWI可以在增强扫描后进行。Objective To evaluate the effect of intravenous Gd-DTPA on DWI of breast. Methods DWI was performed before and after Gd-DTPA injection on 25 patients with breast cancer confirmed by core or fine-needle aspiration biopsy. The signal-to-noise ratio （ SNR）, contrast-to-noise ratio （CNR） and ADC values were measured on DWI when b = 0 and 1000 s/mm^2 were selected. A paired t-test and nonparametric test were used to compare the differences between SNR, CNR and ADC values before and after enhancement in breast cancer and normal breast. Results There were no significant differences between the SNR（34. 56 ± 11.34 and 33.60 ± 14. 34 for cancer, 9. 88 ± 3.16 and 10. 42 ± 4. 18 for normal breast） and CNR （24. 16 ± 9. 05 and 22. 26 ± 10. 05 ） before and after administration of contrast medium in breast cancer and normal breast, and no significant differences between the ADC values before and after administration of contrast medium in breast cancer [ （0. 96 ±0. 13） × 10^-3 vs （0. 95 ±0. 14） × 10^-3 mm^2/s] and normal breast[（1.90 ±0.47） × 10 ^-3 vs （1.91 ±0.61） × 10 ^-3 mmE/s], either （P =0.20 and 0.97）. Conclusion It is possible to repeat DWI acquisition after administration of contrast medium in breast MRI.

关 键 词：乳腺 磁共振成像 扩散 造影剂 

分 类 号：R686[医药卫生—骨科学]