盐酸昂丹琼口腔崩解片的制备  

Preparation of ondansetron hydrochloride orally disintegrating tablets

作　　者：任虹燕[1] 贺建昌[1] 张青[1] 冯恩富[1] 陈燕[1] 庞云丽[1] 徐贵丽[1] 

机构地区：[1]成都军区昆明总医院药学部,云南昆明650032

出　　处：《云南大学学报（自然科学版）》2009年第3期291-294,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：云南省自然科学基金资助项目(2003C0016R)

摘　　要：以微晶纤维素(MCC)、交联聚乙烯吡咯烷酮(PVPP)和泡腾剂为崩解剂制备盐酸昂丹司琼口腔崩解片.以Eudragit E100为载体制备盐酸昂丹司琼包合物以掩蔽其苦麻味,采用粉末直接压片法制备片剂,运用星点设计-效应面法进行处方优化,并对药物体外溶出进行评估.以MCC,PVPP和泡腾剂含量为自变量,体外崩解时间为因变量进行二次多项式拟合,结果表明,拟合的效果较好,较优处方为w(MCC)9%,w(PVPP)6.5%,w(泡腾剂)17.5%.与市售普通片比较,口腔崩解片具有明显速释效果.将盐酸昂丹司琼制成口腔崩解片能显著提高其体外溶出速度.To prepare orally disintegrating tablets of ondansetron hydrochloride with MCC, PVPP and effervescent as disintegrating agent. The grains which contain ondansetron hydrochloride and Eudragit E100 were prepared in order to mask the bitterness of ondansetron hydrochloride. The tablets were prepared by direct compression from powder, and the formulation was optimized by central composite design and response surface methodology. The in vitro dissolution of the tablets was also evaluated. Using the content of MCC ,PVPP and effervescent as independent variable, and in vitro dissolution time as dependent variable ,the equation achieved had good coefficient. The optimized formulation was MCC 5.4 % ,PVPP 5.8% and effervescent 12%. The orally disintegrating tablets had significant fast release effect, compared with marketed tablets. The in vitro dissolution rate of ondansetron hydrochloride can be improved using the formulation of orally disintegrating tablets.

关 键 词：盐酸昂丹司琼 口腔崩解片 星点设计 效应面 

分 类 号：R944.4[医药卫生—药剂学]