无静脉转流猪原位肝移植模型的建立  

THE ESTABLISHMENT OF ORTHOTOPIC LIVER TRANSPLANTATION MODEL WITHOUT VENO-VENOUS BYPASS IN PIG

作　　者：岳根全[1] 孟兴凯[1] 钟海燕[2] 张俊晶[1] 齐力[1] 梁越[1] 乔建梁[1] 任建军[1] 

机构地区：[1]内蒙古医学院附属医院外科,内蒙古呼和浩特010050 [2]内蒙古医学院附属医院麻醉科

出　　处：《内蒙古医学院学报》2009年第2期96-98,共3页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自然科学基金项目(NY2003ZD001)

摘　　要：目的:研究猪原位肝移植术(orthotopic liver transplantation,OLT)的技术难点,为临床应用积累经验,提供依据。方法:施行15例猪OLT,总结手术得失,探讨术中、术后并发症的特点和原因。结果:15例OLT术后存活10例,手术存活率66.7%。术中死亡5例,死因分别为血容量不足、无肝期长、无肝期补液太多、凝血功能障碍、出血及手术方式不合理。术后8h死亡1例,死因为吻合口血栓形成。结论:合理的手术方式、熟练的手术技巧、无肝期和新肝期的合理处理是OLT成功的关键,肝上下腔静脉的暴露吻合是手术的难点。Objective：To study the technique nodus of orthotopic liver transplantation （OLT） in pigs,accumulat experience for clinical application. Methods： 15 cases of OLT operations were performed in pigs to summarize gain and loss of operation, and to investigate the characteristic and cause of complication. Results：After operation 10 cases survival, survival rate was 66. 7% ,5 cases died. The reason were different, including hypovolemia, long anhepatic phase, much fluid infusion in anhepatic phase, coagulation disorders,hemorrhage and unreasonable modus operandi. 1 case died in 8 hours after operation, which reason was thrombosis in anastomotic stoma. Conclusion： The key point in OLT is rea- sonable modus operandi ,skilled operation technics, reasonable treatment in anhepatic phase and neohepatic phase,it is nodus of operation to reveal and anastomose suprahepatic inferior vena cava.

关 键 词：原位肝移植 手术技巧 并发症 猪 

分 类 号：R657.3[医药卫生—外科学]