乙型肝炎肝硬化患者血清IL-18、IL-18结合蛋白a亚群水平的检测及临床意义  

Serum levels of IL-18 and IL-18 BPa in patients with type B hepatitis and cirrhosis

作　　者：冯冰[1] 龙尧[1] 张武英[1] 

机构地区：[1]广东医学院附属医院感染内科,广东湛江524001

出　　处：《广东医学院学报》2009年第2期137-138,共2页Journal of Guangdong Medical College

摘　　要：目的探讨乙型肝炎肝硬化患者血清白细胞介素18(IL-18)和白细胞介素18结合蛋白(IL-18BP)的水平变化及其与病情的关系。方法用ELISA法检测75例乙型肝炎肝硬化患者(Child-Pugh A级、Child-Pugh B级、Child-Pugh C级各25例)和25例正常对照血清IL-18、IL-18BP a亚群(IL-18BPa)水平。结果乙型肝炎肝硬化患者血清IL-18、IL-18BPa水平均明显高于正常对照(P<0.01),并且Child-Pugh A、B、C三级IL-18、IL-18BPa的水平依次递增,各级间差异有统计学意义(P<0.01或0.05)。结论检测血清IL-18、IL-18BP水平有助于判断乙型肝炎肝硬化病情的严重程度,IL-18BP可能不足以中和IL-18。Objective To investigate the relationship between the serum levels of interleukin-18 （IL-18） and IL-18 binding protein （IL-18BP） and disease severity in patients with type B hepatitis and cirrhosis. Methods Serum contents of IL-18 and IL- 18BPa were measured by ELISA in 75 patients with type B hepatitis and cirrhosis （Child-Pugh A, 25 cases; Child-Pugh B, 25 cases; and Child-Pugh C, 25 cases） and 25 normal controls. Results The serum levels of IL-18 and IL-18BPa were significantly higher in patients with type B hepatitis and cirrhosis than those in control group （P 〈 0.01）, and their expression was positively correlated with the Child-Pugh grading （ P 〈 0.01 or 0.05）. Conclusion Serum levels of IL-18 and IL-18BP are helpful in the evaluation of disease severity in patients with type B hepatitis and cirrhosis. IL-18BP may be insufficient to counteract IL-18.

关 键 词：乙型肝炎 肝硬化 白细胞介素-18 白细胞介素18结合蛋白 

分 类 号：R512.62[医药卫生—内科学]