丹皮酚对糖尿病大鼠血管内皮细胞的保护作用  

Effect of Paeonol on Protecting Endothelial Cells of Diabetic Rats

作　　者：闵存云[1] 刘和强[1] 詹锋[1] 丘伟钟[1] 

机构地区：[1]广东省人民医院中医科,广东广州510080

出　　处：《中药材》2009年第4期564-567,共4页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局资助项目(1050036)

摘　　要：目的:观察丹皮酚对糖尿病大鼠血管内皮细胞的保护作用。方法:腹腔注射链脲佐菌素60 mg/kg制备糖尿病动物模型,分别以高、中、低剂量的丹皮酚对模型鼠进行灌胃,分别采用放射免疫法和ELIZA法检测各组大鼠给药前后PG I2、TXA2、ET、NO、CRP、ICAM-1、VCAM-1的变化。结果:各给药组给药前后的血糖值无明显变化,与对照组相比无显著性差异,各给药组大鼠的血清ET、TXA2、CRP、ICAM-1、VCAM-1均有所降低,其中以高剂量组最明显,与对照组相比差异显著(P<0.05或P<0.01);各给药组大鼠的NO稍有升高,但与对照组相比无显著性差异,各给药组大鼠的PG I2α升高,与正常对照组相比有显著性差异。结论:丹皮酚对糖尿病大鼠的血清PG I2、TXA2、ET、NO、CRP、ICAM-1、VCAM-1均有一定的改善作用,可以保护血管内皮细胞。Objective ：To study the effect of paeonol on protecting endothelial cells of diabetic rats. Methods：Streptozocin was used on rats to make diabetic models. Different dosages of paeonol were fed on all the model rats. PGI,TXA2 ,ET,CRP,ICAM-1 ,VCAM-1 and NO were tested after 30 day＇s therapy. Results： Compared with control group PGt increased from 89. 75 ± 2.75,89.97 ± 7.28, 89.97 ± 11.36 to 120. 03 ± 13.85,108.34 ± 11.25,105.32 ± 8.85, respectively. TXA2 decreased from 157.64 ± 10. 36,156. 64 ± 11.35,153.33 ± 19.40 to 124.46 ± 18.67,136. 40 ± 18. 15,138.40 ± 22.20, respectively. ET decreased from 181.68 ± 5. 10,181.27 ± 4. 76,181.04 ± 4. 19 to 140. 55 ± 3.01,150. 51 ± 2.22,161.02 ± 3.76, respectively. CRP decreased from 41.63 ± 7.37,44. 83 ± 7.80,42.06 ±7.21 to 28.62 ±5.45,30.00 ± 10. 73,37.09 ±4. 94, respectively. ICAM-1 decreased from 225.77 ± 11.96,222. 78 ± 14.46,225.17 ± 10. 03 to 190. 93 ± 12.67,197.42 ± 14. 56,200. 64 ± 15.36, respectively. VCAM-1 decreased from 566. 72 ± 24. 46, 560. 61 ±25.67,559. 61 ± 42.75 to 506. 26 ± 37.26,516. 83 ± 28. 17,527.02 ± 43.47, respectively. NO had no change. Conclusions：Paeonol can protect the endothelial cells of diabetic rats.

关 键 词：丹皮酚 糖尿病 血管内皮细胞 

分 类 号：R285.5[医药卫生—中药学]