黄连及其与肉桂药对配伍中盐酸小檗碱在大鼠体内的组织分布研究  

Study on the Tissue Distribution of Berberine from Rhizoma Coptidis and Compatibility with Rhizoma Coptidis and Cortex Cinnamomi in Rats

作　　者：焉巧娜[1] 张朔[1] 张振秋[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《中药材》2009年第4期575-578,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:研究黄连药材提取物及黄连、肉桂药对提取物中盐酸小檗碱在大鼠体内的组织分布特征。方法:灌胃给药,采用HPLC法测定大鼠体内盐酸小檗碱的组织含量,用液-液萃取的方法提取组织样品中的盐酸小檗碱。结果:两种提取物以等剂量灌胃后,相同时间点在组织中,大鼠体内黄连、肉桂药对提取物中盐酸小檗碱的组织含量大于黄连药材提取物中盐酸小檗碱的组织含量。结论:在小肠、大肠、胃、肝、肺、脾、睾丸、心、肾、子宫、胰组织中都能检测到小檗碱,特别是胃肠道系统中的组织浓度较高,表明小檗碱在大鼠体内分布广泛。Objective：To study the effects of Rhizoma Coptidis extracts and Rhizoma Coptidis and Cortex Cinnamomi extracts on the distribution of terberine in rats＇tissues. Methods：The rats were intragastrically given the two different extracts. HPLC was used to determine the concentration of berberine in rats＇ tissues and the sample was extracted by liquid-liquid extraction method. Results：At the same time,with the same garage of the three extracts,the trend of the berberine in rats was ： the concentration of Rhizoma Coptidis and Cortex Cinnamomi extracts 〉 the concentration of Rhizoma Coptidis extracts. Conclusion ： Berberine can be detected in intestinal, stomach, colon, pancreatic, heart , kidney ,liver, spleen, lung, testicular , uterus, especially the gastrointestinal system with higher concentration, so berberine has a wide range of distribution in vivo.

关 键 词：小檗碱 组织分布 

分 类 号：R285.5[医药卫生—中药学]