对芒果止咳片中马来酸氯苯那敏的含量测定  

Determination of Chlorphenamine Maleate in Mangguo Zhike Tablets by HPLC

作　　者：莫慧贞 许则省 

机构地区：[1]广东省阳江市药品检验所,广东阳江529500 [2]广东阳江制药厂有限公司,广东阳江529500

出　　处：《今日药学》2009年第4期40-42,共3页Pharmacy Today

摘　　要：目的建立用高效液相色谱(HPLC)法测定芒果止咳片中马来酸氯苯那敏的含量。方法高效液相色谱法,DiamonsilTM-C18(4.6mm×150mm×0.5μm)色谱柱,以乙腈-0.5%十二烷基硫酸钠溶液-磷酸(60∶40∶0.1)为流动相,检测波长为210nm。结果马来酸氯苯那敏的线性范围为8～40μg/ml(r=0.9999);平均回收率为99.2%(n=6),相对标准差(RSD)为0.52%。结论该方法快速、方便,分离度好,其他成分无干扰,适合用于复方制剂中马来酸氯苯那敏的含量测定。Objective To establish a method for the determination of the content of Chlorphenamine Maleate in Mangguo Zhike tablets. Methods The C,s column （4.6 mm × 150 mm×0.5 μm） was used, the mobile phase was consisted of acetonitrile： 0.5% sodium laurylsulfate ： phosphoric acid （60： 40： 0. 1 ） as a by RP- HPLC, and the detective wavelength was at 210 nm. Results Chlorphenamine Maleate maleate showed good linear ship in the range of 8-40 μg （ r -- 0. 9999）. The average recovery was 99.2% （ n = 6）, RSD = 0. 52%. Conclusion The method is simple, sensitive, accurate, and suitable for the determination of Chlorphenamine Maleate in Mangguo Zhike tablets.

关 键 词：高效液相色谱法 芒果止咳片 马来酸氯苯那敏 

分 类 号：R284.2[医药卫生—中药学]