幽门螺杆菌感染动物模型菌株及其研究进展  

Advances of Helicobacter pylori strains for infecting animal models

作　　者：李晶[1] 张建中[1] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《中国病原生物学杂志》2009年第4期308-310,317,共4页Journal of Pathogen Biology

摘　　要：幽门螺杆菌(Helicobacter pylori,Hp)菌株间基因水平的差异明显,因此在动物实验中,菌株的选择也是决定实验结果的重要方面。目前,动物模型中使用的菌株主要有Hp外的螺杆菌属其他菌株、临床分离株及幽门螺杆菌小动物适应株。这些菌株用于模拟Hp感染人后的病程,以便进行致病机制的研究和治疗效果的评价。本文就建立动物模型过程中使用的主要螺杆菌株及其适应范围作一综述。Genetic variation among different Helicobacter pylori strains is obvious. In animal experiments, choosing an appropriate strain is crucial. Currently, the main strains applied in animal model research are bacterium of the Helieobacter species, except H. pylori, clinical isolates of H. pylori and mouse adapted H. pylori strains. They were used for simulating the natural infection, studying the pathological mechanisms and evaluating the effect of treatments or immunization. In this paper, the advantages and drawbacks of these commonly used strains and their application range were reviewed.

关 键 词：幽门螺杆菌 动物模型菌株 猫胃螺杆菌 感染 综述 

分 类 号：R378.99[医药卫生—病原生物学]