栀子苷乳酸-羟乙酸共聚物微球的制备及其性质研究  

Preparation and characterization of geniposide loaded poly (lactic-co-glycolic acid) microspheres

作　　者：张海燕[1] 万娜[1] 许润春[2] 陈晓燕[1] 郑琴[1] 杨明[1,2] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]成都中医药大学,四川成都610075

出　　处：《中成药》2009年第5期696-700,共5页Chinese Traditional Patent Medicine

基　　金：江西省卫生厅中医科研计划赣卫中字[2007]20号;江西省教育厅科学技术研究项目(GJJ08335)

摘　　要：目的:优化栀子苷(Geniposide)乳酸-羟乙酸共聚物(PLGA)微球的制备工艺。方法:采用改进的复乳化-溶剂挥发法制备栀子苷PLGA微球,HPLC法测定微球的载药量及包封率,扫描电镜(SEM)观察微球的表面形貌,差示扫描量热(DSC)分析微球的包裹情况。结果:在优化条件下制备的栀子苷微球大小均匀,表面光滑圆整,载药量为6.15%,包封率为58.84%,DSC分析结果表明栀子苷能被PLGA材料有效包裹。结论:该制备工艺合理,为制备栀子苷PLGA微球提供了理论依据。AIM ： To optimize the preparation process for the geniposide loaded poly lactic-co-glycolicacid （ PL- GA） microspheres. METHODS： A series of geniposide loaded PLGA microspheres have been prepared by W/o1/ o2 emulsion solvent evaporation method. The process parameters involved were investigated by HPLC with respect to the encapsulation and drug loading. The microspheres resulted with pellet appearance and the entrapment of micro- spheres were analysed by DSC. RESULTS： The obtained geniposide loaded PLGA microspheres had an average diameter showing smooth and round surface. The drug loading of microsphere was 6.15% and entrapment efficiency was 58.84%. Geniposide was successfully incorporated into PLGA microsphere through DSC analyses. CONCLUSION： The research provides an optimized method for the preparation of geniposide loaded PLGA microspheres.

关 键 词：栀子苷 乳酸-羟乙酸共聚物 微球 制备 

分 类 号：R944[医药卫生—药剂学]