模糊聚类法在不同参数电针疗效分析中的应用  

Fuzzy cluster analysis of therapeutic effects of electro-acupuncture at different parameters

作　　者：蒯乐[1] 金如锋[2] 高明[1] 杨华元[1] 

机构地区：[1]上海中医药大学针灸推拿学院中医工程学教研室,上海201203 [2]上海中医药大学基础医学院预防医学教研室,上海201203

出　　处：《中西医结合学报》2009年第5期478-481,共4页Journal of Chinese Integrative Medicine

基　　金：上海市教育委员会科研项目(No.06CZ042)

摘　　要：目的:探讨模糊聚类法在不同参数电针治疗佐剂性关节炎(adjuvant-induced arthritis,AA)大鼠总体疗效分析中的应用。方法:将健康雌性Wistar大鼠100只随机分为10组:正常空白对照组(简称空白组)、模型组和8个电针组,每组10只。用不同参数的电针治疗AA大鼠。应用模糊数学方法对治疗后关节肿胀度、痛阈和炎症局部组织中β-内啡肽和白细胞介素1β含量等各组数据以数据极差正规法进行标准化处理,使用MATLAB编程求解模糊相似矩阵和传递闭包的方法,对不同组别的相似性进行评价。结果:当λ=0.72时,空白组和模型组各为一类;100Hz、连续波、0.2mA电针,100Hz、断续波、0.1mA电针和100Hz、断续波、0.2mA电针聚为一类,这3组参数的电针治疗AA大鼠的疗效相似,消炎止痛效果较好,余电针组疗效相似。结论:模糊聚类法为多因素多组电针多个指标的总体疗效分析提供了一种较好的分析方法。Objective： To probe into the application of fuzzy cluster in analysis of therapeutic effects of electro-acupuncture at different parameters on adjuvant-induced arthritis （AA） in rats. Methods： One hundred Wistar rats were randomly divided into ten groups： normal control group, untreated group and eight electro-acupuncture groups at different parameters. There were ten rats in each group. AA rats were treated by electro-acupuncture at different frequencies （2 Hz or 100 Hz）, waveforms （successive wave or intermittent wave） and current intensities （0.1 mA or 0.2 mA）. Firstly, the anti-inflammatory and analgesic effects of electro-acupuncture at different parameters were compared with orthogonal experiment, and then with the application of fuzzy mathematics, the data of joint swelling, pain threshold and the contents of β-endorphin （β-EP） and interleukin-1β （IL-1β） after the treatment in all groups were standardized by the method of data range normalization. Programming and solution were done by MATLAB. The methods of fuzzy similar matrix and the transitive closure were used in similarity evaluation of therapeutic effects of electro-acupuncture at different parameters. Results： Based on index determination and variance analysis, both the normal control group and untreated group were clustered to one category as A equaled to 0. 72. Electro-acupuncture at 100 Hz, successive wave, O. 2 mA, electro-acupuncture at 100 Hz, intermittent wave, 0. 1 mA and electro-acupuncture at 100 Hz, intermittent wave, 0.2 mA were clustered to one category and had similar good anti-inflammatory and analgesic effects. The therapeutic effects of the remaining electro-acupuncture types were similar. Conclusion： Fuzzy cluster analysis provides a better method for evaluating the overall therapeutic effects of electro-acupuncture with multiple factors.

关 键 词：模糊数学 聚类分析 电针 治疗结果 大鼠 

分 类 号：R245[医药卫生—针灸推拿学]