孕妇高凝状态Pre—DIC／DIC相关检测指标的探讨  

The study of the related examination for Pre-DIC/DIC in pregnant woman

作　　者：王冬娥[1] 邓坤仪[1] 李栓文[1] 

机构地区：[1]南方医科大学附属中山市博爱医院,528403

出　　处：《中国临床实用医学》2009年第3期30-32,共3页China Clinical Practical Medicine

摘　　要：目的探讨孕妇高凝状态Pre-DIC／DIC相关检测指标的临床意义。方法应用Clauss法、凝固法、免疫散射比浊法、发色底物法，分别检测孕妇与健康非孕育龄妇女的Fib、Ⅶ、Ⅷ、Ⅹ、AT—Ⅲ和D—D水平并结合DIC病例进行临床分析。结果孕妇组（n=40）Fib为（4．41±0．72）g／L；Ⅶ（160．30±29．17）％；Ⅷ（143．87±50．30）％；Ⅹ（120．17±18．47）％；AT—Ⅲ（81．28±10．86）％；D—D为（1．56±0．98）mg／L。对照组（n=20）：Fib为（3．05±0．60）g／L；Ⅶ（97．80±11．93）％；Ⅷ（112．00±25．69）％；Ⅹ（93．20±9．31）％；AT—Ⅲ（105．00±7．84）％；D—D为（0．23±0．08）mg／L。孕妇组各项指标与对照组比较差异显著（P〈0．01；P〈0．05）。6例产前孕妇Pre—DIC相关指标检测结果，4例PT在正常参考范围内（11．5～14．5s），2例分别为10．8、16．9s；6例APTT均在正常参考范围内（28．0～43．5s）；4例Fib分别为5．16、5．13、5．10、5．70g／L，2例分别为3．95、2．86g／L；D-D均〉5．00mg／L。10例DIC产妇PT均延长，平均33．98s（15～120s）；APTY平均78．19S（31．6—180S），其中4例在正常参考范围内，分别为40．0、41．0、33．9、31．6s；Fib均〈1．48g/L；D—D平均18．39mg/L（6．24～49．6mg／L）。结论Fib与D—D为孕妇高凝状态Pre-DIC／DIC检测的敏感、实用指标；PT、APTT仅能作DIC检测指标。Objective To explore the clinical meaning of the related examination in Pre-DIC/DIC in pregnant woman. Methods Fib.Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ .D-Dimer in pregnant were detected with clauss method .solidity method, immunoturbidimetric methodrespect and chromozym method, respectively. Result In pregnant woman group（ n =40） ,the level of correlating factors,including Fib, Ⅶ、Ⅷ、Ⅹ、AT-Ⅲ and D-Dimer,were 4.41 g/L ±0.72 g/L, 160.30% ±29.17 %,143.87% ±50.30%,120.17% ± 18.47 %,81.28% ±10. 86% ,1.56 mg/L ±0.98 mg/L, respectively and 3.05 g/L±0. 60 g/L,97.80%± 11.93 % ,112.00% ± 25.69 % ,93.20% ± 9. 31%, 105.00% ± 7. 84% ,0. 23 mg/L ±0. 08 mg/L in control group （ n = 20）, respectively, Reults Of the related examination in pregnant woman group was much higher than that in Control group （P 〈0. 01 or P 〈0.05） PT by two exceptions and APTT in Pre-DIC in pregnant woman （6 Cases） were all normal. Fib and D-Dimer density were all over and above 5 g/L and 6 mg/L,respectively. Conclusion Fib and D-Dimer was a sensitive indication for Pre-DIC/DIC.

关 键 词：孕妇 高凝状态 弥漫性血管内凝血 纤维蛋白原 D-二聚体 

分 类 号：R4[医药卫生—临床医学] R714