低强度脉冲超声对兔关节软骨损伤修复的影响  

The effects of low intensity pulsed ultrasound on repair of articular cartilage injury in rabbits

作　　者：贾小林[1] 陈文直[2] 孙保勇[2] 王智彪[2] 

机构地区：[1]重庆市中山医院骨科,重庆400013 [2]重庆医科大学医学超声工程研究所

出　　处：《中华物理医学与康复杂志》2009年第5期305-307,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：国家“九五”重点科技攻关项目（96-905-02-01）,国家自然科学基金重点项目（396303340）

摘　　要：目的探讨低强度脉冲超声对兔受损关节软骨修复的影响。方法于10只兔双侧股骨髁间窝软骨面处全层钻孔，作为动物模型。术后左后肢膝关节缺损处予以低强度脉冲超声辐射作为治疗组，右后肢膝关节予以假辐射作为对照组。于术后8周全部处死，行大体评分、组织学评分及修复组织中蛋白多糖含量测定。结果治疗组大体评分、组织学评分及甲苯胺蓝染色光密度值均比对照组高，差异有统计学意义（P〈0．05）。结论低强度脉冲超声能促进受损关节软骨修复，且修复组织类似透明软骨。Objective To investigate the effects of low intensity pulsed ultrasound （LIPU） on articular cartilage injury in rabbits. Methods Ten adult New Zealand white rabbits with bilateral, full-thickness osteochondral defects in the cartilage surfaces of intercondylar fossas were used as model. The left knees in these rabbits treated with LIPU were used as experimental group. The right knees treated with sham intervention were used as controls. All the rabbits were sacrificed at the 8th week postoperation for gross appearance grading, histological grading and semi-quantitation of proteoglycan in the repairing tissue. Results Compared with controls, defects treated with LIPU improved significantly as shown by gross appearance grades, histological grades and optical density of toluidine blue at the 8th week postoperation （ both P 〈 0.05 ）. Conclusion LIPU could accelerate repairing of articular cartilage injury.

关 键 词：低强度脉冲超声 软骨 损伤 修复 

分 类 号：R684[医药卫生—骨科学]