PEG-β-CD/NIPAAm水凝胶的辐射制备及药物控制释放研究  

Radiation synthesis of temperature-sensitive β-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery

作　　者：林汉[1] 陈捷[1] 戚昊玲[1] 沈丽[1] 范金辰[1] 曹芳琦[1] 

机构地区：[1]上海大学环境与化学工程学院,上海200444

出　　处：《核技术》2009年第5期375-378,共4页Nuclear Techniques

摘　　要：采用聚乙二醇缩水甘油酯(PEGDE)对β-环糊精(β-CD)进行改性,合成了新型水溶性的β-环糊精大分子单体(PEG-β-CD)。以电子束为辐射源对PEG-β-CD和N-异丙基丙烯酰胺(NIPAAm)混合物水溶液进行辐照,制备了poly(PEG-β-CD/NIPAAm)水凝胶。与PNIPAAm相比,poly(PEG-β-CD/NIPAAm)水凝胶在室温下具有更高的溶胀率以及在温度升到LCST(Lower Critical Solution Temperature,32℃)后具有更快的收缩响应性。以5-氟尿嘧啶(5-FU)作为模型药物的体外释放实验表明,poly(PEG-β-CD/NIPAAm)水凝胶比PNIPAAm的释放时间有所延长。此现象可能归因于环糊精分子与药物分子形成了包合物。In this paper, β-cyclodextrin（β-CD）-based water-soluble macromonomer （PEG-β-CD） was synthesized by reaction of β-CD with poly（ethylene glycol） diglycidyl ether （PEGDE）. A novel temperature-sensitive hydrogel composed of PEG-β-CD and poly（N-isopropylacrylamide） （PNIPAAm） was prepared by E-beam irradiation. Compared with the normal PNIPAAm hydrogel, the obtained hydrogel had a high swelling ratio at room temperature and exhibited faster shrinking kinetics at temperature close to the lower critical solution temperature （LCST）. 5-fluorouracil （5-FU） was chosen as a model drug loaded into the hydrogels, and the release results showed the β-cyclodextrin-containing hydrogels prolonged the release time.

关 键 词：β-环糊精 N-异丙基丙烯酰胺 辐照聚合 温度敏感性水凝胶 药物控释 

分 类 号：O63[理学—高分子化学]