亲属活体肾移植受者119例临床总结  

Clinical analysis of 119 recipients of living related donor kidney transplantation

作　　者：聂海波[1] 于立新[1] 胡卫列[2] 吕军[2] 朱云松[2] 张小明[2] 王蔚[2] 肖远松[2] 邱晓拂[2] 张利朝[2] 

机构地区：[1]南方医科大学南方医院器官移植科,广州510515 [2]广州军区广州总医院泌尿外科,广州510010

出　　处：《广东医学》2009年第5期721-724,共4页Guangdong Medical Journal

基　　金：广东省自然科学基金资助项目(编号:A07005177)

摘　　要：目的回顾总结亲属活体肾移植受者围手术期的临床特点。方法收集119例亲属活体肾移植受者对照同期234例尸体肾移植受者,比较两组供肾热、冷缺血时间、供肾血管长度、植肾手术时间、术后平均住院时间、供受者HLA错配率、术后3d血肌酐下降速度、DGF发生率、急排发生率、1年人/肾存活率。结果亲属活体肾移植组供肾血管长度、供肾热、冷缺血时间、术后平均住院时间、HLA六位点法错配率、DGF、急排发生率均明显小于尸体肾移植组(P<0.01),而手术时间、术后3d血清肌酐下降速度、1年人/肾存活率亲属活体肾移植组均明显大于尸体肾移植组(P<0.01)。结论亲属活体肾移植的近期临床疗效明显优于尸体肾移植,远期(>1年)的临床效果比较有待进一步追踪观察。在有条件、技术成熟的移植中心亲属活体肾移植是患者家族内自救互救的重要途径。Objective To study the clinical features of recipients of living related donor kidney transplantation. Methods Clinical data of 119 recipients receiving living related donor transplantation from March 2005 to 2008 were compared to 234 patients of cadaver donor kidney transplantation during the same period. Comparison of renal hot and cold ischemic time of donor, vessel length of kidney, operation time of transplantation, average postoperative hospital stay, mismatching rate of HLA, reduction of recipient serum creatinine 3 days after operation, incidence rate of DGF and acute rejection, as well as one year survival of patient and the kidney were compared between cadaver donor and living related donor kidney transplantation. Results Living related donor kidney transplantation is better in renal hot and cold ischemic time of donor, vessel length of kidney, operation time of transplantation, average postoperative hospital stay, mismatching rate of HLA, reduction of serum creatinine 3 days after operation in recipients, incidence rate of DGF, incidence of acute rejection, one year survival of patients and the kidney than those of cadaver donor kidney transplantation with significant differences （P 〈 0.01 ）. Conclusion Living related donor kidney transplantation is better than the cadaver donor kidney transplantation in the short time of clinic outcome, while the long time of that clinic outcome need further followup. It is an important way to apply living related donor kidney transplantation in the transplantation centre with good condition and expert.

关 键 词：亲属活体供者 尸体供者 肾移植 

分 类 号：R699.2[医药卫生—泌尿科学] R711.33[医药卫生—外科学]