肿瘤坏死因子α、转化生长因子β1在米非司酮抗早孕蜕膜中的表达  

Expression of tumor necrosis factor alpha and transforming growth factor-beta 1 in decidua

作　　者：蒋晓莉[1] 赵燕[1] 

机构地区：[1]广西医科大学第一附属医院妇产科,南宁市530021

出　　处：《广西医学》2009年第4期466-468,共3页Guangxi Medical Journal

基　　金：广西科学基金(桂科基236026)

摘　　要：目的通过对早孕蜕膜组织中肿瘤坏死因子α(TNF-α)、转化生长因子β1(TGF-β1)表达的研究,探讨米非司酮应用于早孕药物流产的作用机制。方法用免疫组织化学方法(二步法)测定三组(药物流产组30例,人工流产+米索前列醇组20例,人工流产组20例)早孕蜕膜组织中TNF-α、TGF-β1的表达水平。结果用米非司酮的蜕膜组织中TNF-α含量显著升高、TGF-β1含量明显降低(P<0.05)。结论米非司酮可通过升高早孕蜕膜组织中TNF-α、降低TGF-β1的含量而达到抗早孕的目的。Objective To study the anti-early pregnancy mechanism of Mifepristone by investigating the expression of tumor necrosis factor alpha （TNF-α） and transforming growth factor-beta 1 （TGF-β1） in decidua of early pregnancy. Methods Expression of TNF-α and TGF-β1 in decidua of early pregnancy were measured by using immunohistochemical assay （two-step） in 3 groups （drug abortion,n =30）, group 2 （induced abortion ＋ misoprostol,n =20） and group 3 （induced abortion,n =20）. Results The expression of TNF-α and TGF-β1 in group 1 were significantly higher than the other groups （P 〈 0. 05 ）. Conclusion Mifepristane can prevent pregnancy by increasing the TNF-α and TGF-β1 in decidua of early pregnancy.

关 键 词：药物流产 米非司酮 肿瘤坏死因子Α 转化生长因子Β1 蜕膜 

分 类 号：R714.1[医药卫生—妇产科学] R392.1[医药卫生—临床医学]