多潘立酮微乳的制备及质量评价  

Preparation and Quality Evaluation of Domperidone Microemulsion

作　　者：秦金淼[1] 李引亁 薛琴[1] 薛芬[1] 张海亮[1] 庞丽娜[1] 王倩[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100

出　　处：《西北农业学报》2009年第3期33-37,共5页Acta Agriculturae Boreali-occidentalis Sinica

摘　　要：通过滴定法绘制伪三元相图，根据相图优选处方，并初步考察微乳制剂的稳定性、形态粒径和理化性质。用紫外分光光度（Uv-Vis）法测定微乳中多潘立酮的含量。结果表明，制备出的多潘立酮微乳处方是聚氧乙烯氢化蓖麻油（RH-40）／肉豆蔻酸异丙酯（IPM）／多潘立酮／蒸馏水。微乳稳定，透射电镜下呈圆球形，分布均匀，平均粒径12．4nm。在1-50μg／mL浓度范围内，浓度与吸光度的线性关系良好，平均回收率为（99．41±1．17）％，RSD为1．18％（n=5）。多潘立酮微乳应低温（4℃）、避光保存。该处方设计合理，方法可靠。The optimum formulation was investigated by using titration to prepare the Pseudo-ternary phase diagram, testing the size distribution, stability and physico-chemical property of domperidone microemulsion. Content of domperldone was determined by UV-Vis. The results were as follows. The domperidone microemulsion delivery could be prepared using RH-40/ IPM/domperidone/Water. The stability of domperidone microemulsion was good, and average size was 12.4 nm. Calibration curve was linear in the range of 1μg/mL-50μg/mL the average recovery was （99.41±1.17）%, with RSD of 1.18%（n=5）. Domperidone microemulsion should be stored at low temperature （4°C） and away from light. The formulation is reasonable and the method is accurate.

关 键 词：多潘立酮 微乳 (伪)三元相图 质量评价 

分 类 号：R94[医药卫生—药剂学]