黄体酮在奶牛体内的药物动力学  

The Pharmacokinetics of Progesterone in Cows

作　　者：庞利娜[1] 李引乾[1] 黄冻[1] 张海亮[1] 梅雪洁[1] 杨烨 韩冰 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]国营西安草滩制药厂,陕西西安710021 [3]陕西西乡长江动物药品有限责任公司,陕西西乡723500

出　　处：《西北农业学报》2009年第3期47-50,共4页Acta Agriculturae Boreali-occidentalis Sinica

摘　　要：分析黄体酮(Progesterone)在奶牛体内的药物代谢动力学过程。试验前,奶牛进行摘除卵巢手术,术后30 d单剂量肌肉注射不孕奶牛催乳注射液(含黄体酮与苯甲酸雌二醇),120 h内不同时间15次颈静脉采血,用放射免疫分析法(RIA)测定血清黄体酮浓度。结果表明,黄体酮在奶牛体内的药物动力学配置属于有吸收因素二室模型,其药时曲线方程为C=5.0600e-0.0581t+1.5360e-0.0091t6.5960e-0.3078t。消除相半衰期为(81.6135±24.3323)h,药时曲线下面积为(230.6931±48.5255)ng/(mL.h),达峰浓度为(3.798±1.083)ng/mL,达峰时间为(8.0±1.9)h。黄体酮在奶牛体内分布广泛,消除缓慢。Pharmacokinetics parameters of progesterone in cows were calculated so as to provide proof to veterinary clinic. Four cows after ovariectomy were treated with a single dosage of injection of progesterone and estradiol benzoate intramuscular injection, while the blood samples were collected from vein within 120 hours after giving drug. The concentrations of Progesterone in serum were determined by radioimmunoassay （RIA）. The two-compartment model with absorption factor adequately described concentrations of Progesterone in serum disposition and the best concentration-time equation was C=5.0600e^0.0581t＋1.5360e^0.0091t-6.5960e^0.3078t. The primary pharmacokinetics parameters of progesterone in cows were as follows： Half-time of elimination phase （t1/2β） was （81. 61354±24. 3323） h, Area under curve （AUC） was （230. 6931±48. 5255） ng · mL^-1 · h, Peak concentration （Cmax） was （3. 7984±1. 083） ng/mL, and Time to peak （Tmax） was （8.0±1. 9） h. The distribution of progesterone in cows was abroad, and the elimination of progesterone in cows was slowly.

关 键 词：黄体酮 奶牛 药物代谢动力学 

分 类 号：S858.23[农业科学—临床兽医学]