体外受精-胚胎移植周期的黄体支持方法  

Luteal Support for IVF-ET Cycles

作　　者：王文璇[1] 章汉旺[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科生殖中心,武汉430030

出　　处：《国际生殖健康／计划生育杂志》2009年第3期141-144,共4页Journal of International Reproductive Health/Family Planning

摘　　要：黄体支持治疗可提高体外受精-胚胎移植(IVF-ET)周期的成功率。查阅近十年IVF-ET周期黄体支持药物及黄体支持方法的相关文献,总结发现肌注孕酮为最常用药物,疗效肯定;各种剂型阴道用孕酮与肌注孕酮作用相似甚至更佳,更易为患者接受;口服孕酮阳性研究结果甚少,当前不推荐使用;与孕酮相比,人绒毛膜促性腺激素(hCG)用于黄体支持的继续妊娠率无显著差异,因其可能导致卵巢过度刺激综合征(OHSS),应用受到限制;于黄体早期开始且较大剂量补充雌激素可能改善妊娠结局,是否将其常规用于黄体支持及其安全性还需进一步研究;多数生殖中心从采卵日起给予黄体支持直至妊娠十周左右。Luteal support can increase the success ratio of in vitro fertilization-embryo transfer （IVF-ET） cycles. After reviewing the relevant domestic and foreign literatures for past ten years about luteal support medications and different protocols in IVF-ET cycles, it has been found that： intramuscular injection of progesterone is the most commonly used medication with positive results; Compared with intramuscular progesterone, vaginal progesterone of various formulations can be accepted by patients more easily for its similar or even better effects; Oral progesterone is not recommended for its very few positive results; The application of human chorionic gonadotrophin （hCG） is limited for its similar outcomes of continual pregnancy rates compared with progesterone and its possibility to cause ovarian hyperstimulation syndrome （OHSS）; Estrogen supplement with larger doses during the early luteal phase may improve the pregnancy outcomes, but further safety studies are needed to determine whether this method can be adopted as a routine therapy for luteal support; And luteal supports from the day of ovum pick-up to pregnancy with 10 weeks are performed in most reproductive centers.

关 键 词：体外受精.胚胎移植 黄体支持 黄体酮 绒毛膜促性腺激素 雌激素类 

分 类 号：R714.8[医药卫生—妇产科学]