胎盘绒毛组织孕激素受体表达与分娩发动的关系  

Association between progesterone receptor expression in human placenta chorionic tissues and labor onset

作　　者：姜子燕[1] 肖云山[1] 孙丽洲[1] 

机构地区：[1]南京医科大学第一附属医院妇产科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2009年第5期711-714,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：2008年江苏省六大人才高峰基金资助

摘　　要：目的:探讨胎盘绒毛组织孕激素受体(progesterone receptor,PR)表达变化与分娩发动的关系。方法:采用免疫组化和Westernblot印迹杂交法检测正常足月剖宫产产妇胎盘绒毛组织(临产组15例,未临产组15例)孕激素受体表达变化情况。结果:免疫组化结果显示15例未临产组均存在核PR染色阳性,15例临产组出现弱阳性结果。Westernblot结果显示,临产组PR-A表达量较未临产组下调,同时临产组PR-B表达量较未临产组也下调,两者均存在显著性差异,具有统计学意义(P<0.01);临产组PR-A/PR-B较未临产组高,存在统计学意义(P<0.05)。结论:PR-A/PR-B比值升高可能是参与分娩发动的机制之一。Objective：To disscuss the relationship between progesterone receptor （PR）expression in human placenta chorionic tissues and labor onset . Methods： PR protein levels and cellular localization were measured by immunohistochemistry and Western blot, respectively,in term pregnancy placenta tissue .Two clinical groups were selected：woman in labor （n = 15）and not in labor （n = 15）. Results： PR immunostaining in placenta tissues of women not in labor was positive, and slightly positive in placenta tissues of women in labor. PR-A and PR-B levels decreased in labor group （P 〈 0.01） by Western blot. The PR-A to PR-B protein ratio also increased in labor group（P 〈 0.05）. Conclusion：An increased PR-A to PR-B ratio may participate in the process of labor onset.

关 键 词：胎盘绒毛组织 分娩发动 孕激素受体 PR-A/PR-B 

分 类 号：R714.3[医药卫生—妇产科学]