肝癌的动态CT灌注成像具有可重复性  

Reproducibility of multi-slice CT perfusion imaging for liver cancer

作　　者：周丹[1] 陈晓晖[1] 郭金和[1] 何仕诚[1] 闵捷[2] 滕皋军[1] 

机构地区：[1]东南大学临床医学院,江苏南京210009 [2]东南大学公共卫生学院,江苏南京210009

出　　处：《南京医科大学学报（自然科学版）》2009年第5期715-720,共6页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:研究肝癌的动态CT灌注成像(CTP)的可重复性。方法:采用德国Siemens sensation64层螺旋CT机,应用BodyPCT肝脏灌注软件进行处理,该软件应用的数学模型是斜率法和Patlak分析法。首先建立一个相对一致的标准后处理方法,应用软件处理后得到灌注彩图,用鼠标划出各感兴趣区,包括按肿瘤大小和按肿瘤直径一半划出的兴趣区(ROI)。然后建立1个后处理对比的方法,观察观测者之内的可重复性:2个技能和经验都不相同的观测者(甲、乙)采用双盲法分别进行(CTP)的后处理。分别对甲和乙的前后2次后处理的结果进行统计学分析,评价其前后2次后处理的一致性;观察观测者之间的可重复性:对甲和乙后处理分析的数据进行比较,评价不同操作人员对CTP可重复性的影响。结果:在第1次后处理时,甲乙2人有一致性;甲前后2次后处理有一致性;乙前后2次后处理也有一致性。结论:肝癌的动态CT灌注成像具有可重复性。Objective：To evaluate the reproducibility of dynamic CT perfusion（CTP）imaging for liver cancer. Methods： Multi-slice spiral CT（Siemens sensation 64, Germany）was used and the data was processed with liver perfusion software-Body PCT,for which the mathematical model of slope and the analysis method of Patlak was used. First,a relative coincident and standard post-processing method was established. CT perfusion image was obtained after software processing,and each ROI was marked out with mouse,including the size of the tumor and the half-diameter ROI of the tumor. Then a post-processing method for comparison was built up： （1）To observe the reproducibility of the same operator：The operators who have different skills and experience（A and B）separately made the post-processing of CTP. The pest-processing results from the same operator were statistically analyzed and the consistency was evaluated. （2）To observe the reproducibility between the two operators：The results from the two operators were compared to evaluate the effects of different operators on the reproducibility of CTP. Results：The result from operator A was consistent with that from B for the first time; and there was also a good consistency between the results from the same operator. Conclusion：Dynamic CT perfusion imaging in liver cancer is a reproducible method.

关 键 词：灌注 肝癌 可重复性 体层摄影术 X线计算机 

分 类 号：R814.42[医药卫生—影像医学与核医学]