CT灌注成像评价PAOD兔后肢慢性缺血模型的实验研究  

Assessment of muscle perfusion in ischemic rabbit hindlimb with perfusion CT

作　　者：曾祥柱[1] 李选[1] 

机构地区：[1]北京大学第三医院放射科,北京100083

出　　处：《当代医学》2009年第5期12-14,共3页Contemporary Medicine

摘　　要：目的初步探讨CT灌注成像(CT Perfusion)在评价外周动脉梗阻性疾病(PAOD)兔后肢缺血模型中骨骼肌组织的应用价值。方法对14只新西兰大白兔建立一侧后肢的缺血模型,分别于术后3,7,14,21,28,42及56天行CT灌注成像检查,原始灌注图像经CTPerfusion软件处理,分析两侧后肢感兴趣区(ROI)的时间——密度曲线(TDC)及相关灌注参数特点及差异。结果术后手术侧肢血流灌注较对侧急剧减低,术后7天内灌注恢复非常缓慢,从14天起灌注恢复逐渐加快,各项灌注指标(BF、BV、MTT及PS)较健侧均有明显差异至56天接近正常水平,但血流量(BF)仍有差异。结论CT灌注成像能够安全、无创、定量并且较准确的评估动物后肢缺血模型随时间推移发生的肌肉组织灌注变化。AIM： To evaluate the application of CT perfusion in the assessment of muscle perfusion in hind-limb ischemia model of rabbit. METHODS： Ischemia was induced in right hind limbs of 14 New Zealand white rabbits by complete excision of femoral artery. 3, 7, 14, 21, 28, 42, 56 days after the model establishment, CT perfusion scan was performed on models respectively and draw a time-density curve. The perfusion curve and parameters （BF, BV, MTr, PS） were analyzed. RESULTS： Following femoral artery excision, a rapid reduction of muscle perfusion in the hind-limb was observed. Perfusion recovered very slowly during the first 7 days, faster perfusion recovery was observed within 14 to 56 days, but at last BF did not reach the normal level. CONCLUSION： CT perfusion imaging is a safe, noninvasive, quantitative and relatively accurate technique to assess time-dependent changes of muscle perfusion in hind-limb ischemia model of rabbit.

关 键 词：CT成像 灌注 缺血 外周动脉梗阻性疾病 动物模型 

分 类 号：R654.3[医药卫生—外科学] R816.2[医药卫生—临床医学]