不同浓度腺苷对肥胖症大鼠离体空肠平滑肌活动及肠系膜微循环的影响  

Effects of Adenosine on the Movement of Isolated Jejunum and the Mesentery Microcirculation in Nutritional Obese Rats

作　　者：刘洋[1] 李俊[1] 武晓灵[1] 余上斌[1] 刘声远[1] 

机构地区：[1]华中科技大学同济医学院机能学中心实验室,武汉430030

出　　处：《微循环学杂志》2009年第2期22-24,共3页Chinese Journal of Microcirculation

摘　　要：目的:探讨腺苷对肥胖症大鼠离体空肠平滑肌活动及肠系膜微循环的影响。方法:实验分为普通饲料喂养大鼠组(A组)和高能量饲料喂养肥胖大鼠模型组(B组)。检测腺苷干预时肥胖症大鼠脂肪/体重比(L/W)?血清甘油三酯(TG)和总胆固醇(TC)水平?空肠平滑肌活动幅度(-dT)?主动张力最大舒张速率(-dT/dt-max)、Lee′s指数以及肠系膜微循环指标的变化。结果:(1)B组大鼠体重?L/W?Lee′s指数?TG、TC及腺苷浓度在200μmol/L时-dT/dtmax均高于A组(P<0.05～0.01)。(2)B组大鼠空肠平滑肌-dT低于A组(P<0.05)。(3)B组大鼠腺苷干预前微血管口径大于A组(P<0.05);血流速度小于A组(P<0.01),腺苷干预(浓度200μmol/L)后血流速度明显大于腺苷干预前(P<0.01),血液流态改善为线流。结论:腺苷可明显改善肥胖症大鼠空肠平滑肌活动和肠系膜微循环。Objective:To observe the effects of adenosine(CPA)on the movement of isolated Jejunum from obesity rats and mesentery microcirculation.Method:The rats were divided into two groups:one group were raised by normal food(group A),another were raised by high-energy food(group B).The belly fat total cholesterol and lipid in the blood,the Lee's index,and the effects of CPA on the frequency,extent,maximal velocity of relaxation(-dT/dt max)of isolated jejunum and the mesentery microcirculation of rats were studied.Results:(1)The body weight,the belly fat/weight,Lee's index,maximal velocity of relaxation(-dT/dt max)in group B were higher than those in group A(P<0.05～0.01)when the concentration of CPA is 200μmol/L.(2)The extent of the movement of isolated Jejunum in group B was lower than that in group A(P<0.05).(3)Before the treatment with CPA,the vascular diameter of mesenteric microcirculation in group B was less than group A(P<0.05),and the blood flow rate of group B was less than group A(P<0.01).But when the CPA was given to group B,the blood flow rate of group B was significantly higher than group A,especially at the level of 200 μmol/L;and the state of blood flow of group B was changed to linear flow.Conclusion:CPA may improve the movement of smooth muscle of Jejunum and the microcirculation of mesentery in obese rats obviously.

关 键 词：大鼠肠系膜 肠系膜微循环 离体空肠 肥胖症 肌活动 腺苷 平滑 浓度 

分 类 号：R971[医药卫生—药品] R512.6[医药卫生—药学]