针刺内关穴与非穴的fMRI脑功能成像研究  

An fMRI cerebral functional imaging study on needling in Neiguan(PC6)vs a sham point

作　　者：张贵锋[1] 赖新生[2] 黄泳[1] 吴俊贤[1] 曾统军[1] 李赣龙[1] 邹燕齐[1] 

机构地区：[1]南方医科大学,广东广州510515 [2]广州中医药大学,广东广州510405

出　　处：《辽宁中医杂志》2009年第5期810-812,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2006CB504505);国家自然科学基金重大研究计划课题(90709027)

摘　　要：目的:观察针刺健康志愿者右侧内关穴和非穴时不同脑区的激活情况,探讨针刺穴位对脑中枢的激活效应。方法:将14例健康志愿者随机分为内关穴组和非穴组,分别针刺右侧内关穴和非穴;同时,运用GE公司1.5T超导核磁共振系统完成脑部fMRI扫描,获得局部脑组织激活与否的试验数据,采用感兴趣区(ROI)法进行处理和分析。结果:针刺内关穴和非穴,对双侧顶叶、额叶、枕叶、颞叶、基底节区、扣带回、小脑、脑桥、脑岛等多个脑区分别有不同程度的激活;从激活几率、激活数量和激活强度上看,针刺右侧内关穴以激活左侧顶叶、额叶、颞叶、枕叶为主,并且特异性激活左侧海马和双侧桥脑;尽管在脑区的激活上,有上述趋势,但是在统计学上无显著性意义(P>0.05)。结论:针刺内关穴和非穴激活的脑区有相对的差异性,针刺外周穴位能特异性的激活脑中枢。Objective：To observe cerebral activation of healthy volunteers received needling Neiguan vs a sham point in the right hands, and to explore activation effect of acupoint needling on the central brain. Methods：Fourteen healthy volunteers were randomly divided into Neiguan true group and sham point group, and received needling in PC6 and the sham point respectfully. Super nuclear magnetic resonance（ 1.5T,from GE Company）was used to scan the brain and the obtained experimental data in the regional brain were processed and analyzed by the method of Region of Interest （ROI）. Results：Many cerebral areas such as the bilateral parietal lobes, frontal lobes, occipital and temporal lobes, basal ganglia, cingulate gyry, cerebellum, pons, and the insular lobes were activated in varying degrees in both the Neiguan and sham point needling groups. The comparison of the activating rate, activating number and activating intensity, showed that there was the trend that needling in right Neiguan mainly activated the left parietal lobe, frontal lobe, temporal lobe and occipital lobe, and specially activated the left hippoeampus and bilateral pons. But no significant difference was found between the two groups （P 〉 0. 05）. Conclusion：There was a relative difference for the activated cerebral area between Neiguan sham needling. Acupoint needling could activate special central cerebral areas.

关 键 词：内关穴 非穴 FMRI 脑功能成像 中枢效应 

分 类 号：R246[医药卫生—针灸推拿学]