等容血液稀释和超氧化物歧化酶抗再灌注心律失常作用  

THE EFFECTS OF ISOVOLUMETRIC HEMODILUTION AND SUPERXIDE DIMUTASE ON REPERFUSION ARRHYTHMIAS IN RABBIT

作　　者：李秀莲[1] 王柏生[2] 汤宁[2] 吕杰胜[2] 黄幼田[2] 

机构地区：[1]河北省秦皇岛市第一医院心内科,066000 [2]河南医科大学病理生理教研室,郑州450052

出　　处：《中国血液流变学杂志》1998年第1期16-18,50,共4页Chinese Journal of Hemorheology

摘　　要：结扎兔冠脉左室枝４５ｍｉｎ，再灌注１８０ｍｉｎ，复制心肌缺血再灌注模型，观察等容血液稀释和超氧化物歧化酶（ＳＯＤ）对兔再灌注心律失常（ＲＡ）的作用，４０只动物随机分为 ４组：Ⅰ组（对照组）、Ⅱ组（稀释组）、Ⅲ组（ＳＯＤ组）和 Ⅳ组（稀释 ＋ ＳＯＤ组）。结果：与 Ⅰ 组比，Ⅱ，Ⅳ组 ＲＡ发生率显著降低（Ｐ＜０．０５），Ⅱ组 Ｒ Ａ发生率有下降趋势，但无统计学差异。提示：ＳＯＤ及与等容血液稀释联用均能降低ＲＡ的发生，单用等容血液稀释的抗ＲＡ作用有待进一步研究。In this study, with the models of myocardial ischemia and reperfusion in rabbit, we observed the effects of isovolumetric hemodilution and superoxide dismutase (SOD) on reperfusion arrhythmias (RA). The incidence of ventricular premature beats, venticular tachycardia and ventricular fibrillation in Group I and IV decreased significantly as compared with those in Group I (p<0. 05). There was no significant difference between Group I and I though a declining tendency was observed. So the effect of isovolumetric hemodilution alone on RA remained to be studied

关 键 词：心律失常 血液稀释 超氧化物歧化酶 血液疗法 

分 类 号：R541.705[医药卫生—心血管疾病] R457[医药卫生—内科学]