头孢哌酮他唑巴坦配伍含果糖氯化钠溶液的稳定性考察  

Investigation of Compatible Stability of Cefoperazone/Tazobactam for Injectionin Sodium Chloride Injection Containing Fructose

作　　者：李雪松[1] 杨龙[1] 钱斌[1] 李小军[1] 晏远志[1] 杨家爱[1] 

机构地区：[1]昆明医学院第一附属医院药剂科,云南昆明650032

出　　处：《中国药业》2009年第10期24-25,共2页China Pharmaceuticals

摘　　要：目的考察头孢哌酮他唑巴坦在含果糖的0.9%氯化钠溶液中的稳定性。方法观察配伍液室温放置6h内的外观并测定pH,采用高效液相色谱法测定配伍液的含量变化。结果配伍液放置6h内的外观、色泽均无明显变化,pH略有变化,头孢哌酮、他唑巴坦含量均保持在95%以上,无新物质产生。结论头孢哌酮他唑巴坦在含果糖氯化钠溶液中配伍后于室温放置6h内性质基本稳定。Objective To study the compatible stability of Cefoperazone Tazobactam for Injection in 0. 9% Sodium Chloride Injection containing fructose. Methods The content of the compatible solution in 0.9% Sodium Chloride Injection was determined at different time by HPLC; the appearance of the solution was observed and its pH value was determined. Results No significant differences were noted for the compatible solution in appearance, pH value and contents within 6 h after mixing. The content of CefoperazoneTazobactam was more than 95%. No new substance was produced. Conclusion The compatible solution of CefoperazoneTazobactam for Injection and 0. 9% Sodium Chloride Injection containing fructose can be used within 6h under room temperature.

关 键 词：头孢哌酮他唑巴坦 果糖 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学] R978.11[医药卫生—药学]