缅甸拉咱市氯喹治疗间日疟的敏感性评价  

Sensitivity of Plasmodium vivax to Chloroquine in Laza City,Myanmar

作　　者：梁桂亮[1] 孙晓东[2] 王剑[2] 张再兴[1,2] 

机构地区：[1]大理学院基础医学院,大理学院病原与媒介生物研究所,大理671000 [2]云南省寄生虫病防治所,云南省疟疾防治中心,普洱665000

出　　处：《中国寄生虫学与寄生虫病杂志》2009年第2期175-176,共2页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：第五轮中国全球基金疟疾项目硕士研究生培养专项基金(No.2007-03)~~

摘　　要：缅甸拉咱市单纯间日疟原虫感染者48例分为氯喹A方案组(26例)和B方案组(22例),分别采用成人总剂量1200mg(第1天顿服600mg,第2、3天300mg/d)和1500mg(第1天顿服750mg,第2、3天375mg/d)的三天疗法治疗。于服药当天、服药后第1、2、3、7、14、21和28天采集指血或耳垂血制作厚、薄血涂片检查疟原虫,测量体温和观察药物不良反应。氯喹治疗后,两组病例血内无性体原虫3d内全部阴转。第28天随访治愈率为100%。结果表明,缅甸拉咱市的间日疟病例对氯喹治疗均敏感,该边境地区间日疟病例可采用氯喹进行临床治疗。Fourty-eight patients infected by Plasmodium vivax were randomly divided into chloroquine regimen groups A and B. Each case in group A received a total dosage of 1 200 mg（base） over a 3-day period （600 mg on the first day then 300 mg daily）. Cases in group B each received total dosage of 1 500 mg （base） in 3 days （750 mg on the first day then 375 mg daily）. Body temperature and blood smears were examined on days 0, 1, 2, 3, 7, 14, 21 and 28, respectively. All patients were negative for asexual parasites within 3 days. The cure rate on day 28 was 100%. Results showed that P. vivax is sensitive to chloroquine in Laza, Myanmar, and chloroquine can still be used for the imported vivax malaria cases at the China-Myanmar border.

关 键 词：缅甸 间日疟原虫 氯喹 敏感性 

分 类 号：R531.31[医药卫生—内科学]