抗着丝点抗体71例临床分析  

THE CLINICAL ANALYSIS WITH 71 CASES WITH ANTICENTROMERE ANTIBODIES

作　　者：唐福林[1,2,3,4] 占小海 李明佳[1,2,3,4] 汪国生 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院 [2]首都矿山医院 [3]北京红十字朝阳医院 [4]安徽省立医院

出　　处：《中华风湿病学杂志》1998年第1期17-20,共4页Chinese Journal of Rheumatology

摘　　要：目的：为研究抗着丝点抗体（ＡＣＡ）与临床疾病的关系。方法：回顾性总结了７１例ＡＣＡ阳性患者的临床资料。结果：ＡＣＡ可在多种疾病中出现，其中系统性硬化症３０例（４２２％），干燥综合征１０例（１４１％），系统性红斑狼疮６例（８５％），类风湿关节炎５例（７％），局限型硬皮病５例（７％），仅有雷诺现象但诊断不清者４例（５６％），ＣＲＥＳＴ综合征、重叠综合征、不明原因肝硬化、闭塞性脉管炎各２例（２８％），原发性胆汁性肝硬化、硬化性胆管炎、黄褐斑合并白癜风各１例（１４％）。结论：ＡＣＡ相关的临床症状为雷诺现象（５７７％）和皮肤硬化（５３５％）。ＡＣＡ并非ＣＲＥＳＴ综合征的特异性抗体。Objective:To study the association of anticentromere antibodies (ACA) with various diseases.Methods:A total of 71 patients with positive ACA were retrospected.Results:There were 30 patients with systemic sclerosis (422%),10 with Sjogren′s syndrome(141%),6 with systemic lupus erythematosus (85%),5 with rheumatoid arthritis and localized sclerosis (70%) respectively,4 with only Raynaud′s phenomenon without any definite diagnosis (56%),2 with CREST syndrome,overlap syndrome,cirrhosis of unknown causes and buerger′s disease (28%) respectively,and 1 with primary billiary cirrhosis,sclerous cholangitis,and chloasmavitiligo (14%) respectively.Conclusion:The major clinical characteristics of the patients correlated with ACA are Raynaud′s phenomenon (577%) and scleroderma(535%).ACA are not specific for CREST syndrome.

关 键 词：抗着丝点抗体 疾病 系统性硬化症 干扰综合征 

分 类 号：R392.11[医药卫生—免疫学] R363[医药卫生—基础医学]