基因组学研究在抑郁症发病机制及诊断中的应用  

Application of Genome Study on Pathogenesis and Diagnosis of Depression

作　　者：段冬梅[1] 图娅[2] 陈利平[1] 吴整军[1] 

机构地区：[1]中国人民解放军总医院中医针灸科,北京100853 [2]北京中医药大学针灸学院,北京100053

出　　处：《中华中医药学刊》2009年第5期944-948,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30701122)

摘　　要：抑郁症的流行病学研究提示了遗传因子的作用,连锁和关联研究未得出一致性的结果,这些研究主要涉及某些候选基因,如5-羟色胺受体基因、多巴胺受体基因、单胺氧化酶基因等。最近大多数实验结果提示:抑郁症的遗传易感性是多基因的,其作用效果依赖于生理、心理、环境因素的相互作用。Epidemiological studies on depression have indicated the effect of genetic factor, divergent conclusions have been got in linkage and association studies, which involving some candidate genes, such as 5 - HT receptor gene, dopamine receptor gene, monoamine oxidase gene, etc. Recently, most experiments suggested that, genetic susceptibility to depression is most likely polygenic, which is based on the interaction of physiological, psychological and environmental factors.

关 键 词：抑郁症 基因组 

分 类 号：R2-03[医药卫生—中医学]