活血祛湿法对黄疸大鼠肝细胞及微胆管保护作用研究  

Study of Promoting Blood Circulation Qushi Method on Jaundice Rat Liver Cells and Micro-duct

作　　者：吴百灵[1] 卢秉久[1] 杨新莉[1] 阎斌[1] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中华中医药学刊》2009年第5期1013-1014,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省教育厅科研项目(20060506)

摘　　要：目的:探讨活血祛湿法对黄疸大鼠肝细胞及微胆管保护作用。方法:利用α-萘异硫氰酸酯灌胃诱导大鼠急性肝损伤。观察大鼠ALT、AST、TBIL、DBIL、ALP、GGT、MPO、LPO及光镜下肝脏病理学变化。评价活血祛湿法对肝细胞及微胆管的保护作用。结果:活血祛湿法能使α-萘异硫氰酸酯所致肝损伤生化指标及肝脏病理明显改变。结论:活血祛湿法对α-萘异硫氰酸酯所致黄疸大鼠肝细胞及微胆管具有保护作用,其机理可能与降低脂质过氧化物含量有关。Objective：Discussion promoting blood circulation Qushi method effect on jaundice rat liver bile duct cells and micro - protective. Methods： The use of α- naphthyl isothiocyanate induced by oral administration in rats with acute liver damage. Rats ALT, AST, TBIL, DBIL, ALP, GGT, MPO, LPO and liver pathological changes in the light microscope. Qushi evaluation method of activating blood and liver cells of the bile duct micro - protective effect. Results： Qushi promoting blood circulation method can ct - naphthyl isothiocyanate - induced liver injury and liver biochemical indicators of pathological changes. Conclusion： Qushi promoting blood circulation on α- naphthyl isothiocyanate jaundice caused by rat liver bile duct cells and micro - protective role. The mechanism may be related to lower lipid peroxide content.

关 键 词：Α-萘异硫氰酸酯 活血祛湿法 黄疸 

分 类 号：R259.74[医药卫生—中西医结合]