有氧耐力训练对壬基酚染毒大鼠血中心钠素水平的影响  

Effects of Aerobic Endurance Training on Atrial Natriuretic Peptide of Nonylphenol Exposed Rats

作　　者：孙慧群[1] 刘俊[2] 盛守祥[3] 

机构地区：[1]安庆师范学院环境科学学院,安徽安庆246011 [2]安庆师范学院体育系,安徽安庆246011 [3]中国矿业大学资源与安全学院,北京100083

出　　处：《环境与健康杂志》2009年第5期409-411,共3页Journal of Environment and Health

基　　金：安徽省教育厅自然科学基金资助项目(2005KJ371zc)

摘　　要：目的探讨有氧耐力训练对壬基酚(NP)染毒大鼠心血管内分泌功能的影响。方法将8周龄健康清洁级SD雄性大鼠72只随机分为0、11、44、176 mg/kg NP染毒训练和未训练组,每组9只。采用腹腔注射方式染毒,染毒剂量为5 ml/kg,连续染毒8周。训练组进行无负重有氧耐力游泳,每天游泳1次,每次90 min,每周6次。测定血浆心钠素(ANP)含量。结果与未训练对照组比较,0、11 mg/kg NP染毒训练组大鼠ANP水平较高,44、176 mg/kg NP染毒训练组和44、176 mg/kg NP染毒未训练组大鼠ANP水平较低,差异均有统计学意义(P<0.01)。与同剂量未训练组比较,0、11、44、176mg/kg NP染毒训练组大鼠ANP水平较高,差异均有统计学意义(P<0.05或P<0.01)。且无论是训练组还是未训练组,大鼠ANP水平均随NP染毒剂量的升高而降低。结论有氧耐力训练对NP染毒大鼠ANP水平的降低具有拮抗作用。Objective To investigate the affects of aerobic endurance training on the endocrine function of the cardiovascular under the different conditions of unexposed and exposed to nonylphenol （NP） in the rats. Methods Seventy-two rats were randomly divided into 8 groups： unexposed control group, unexposed training control group, the low, moderate and high dosage quiet exposed groups, the low, moderate and high dosage training exposed groups, nine rats in each group. The training group without loading aerobic endurance swimming, the low, moderate and high dosage exposed to NP at doses of 11,44,176 mg/kg, respectively, the concentrations of plasma of atrial natriuretic peptide （ANP） for each group were determined during the experiment. Results ANP of the training control group was significantly increased compared with the quiet control one （P〈0.01） ; the concentration of ANP decreased gradually with the increasing of the exposed NP dosage, there was no significant difference was observed between the low dosage quiet exposed group and the unexposed control one （P〉0.05）, but the moderate and high dosage ones presented obvious decreasing trend than the unexposed control one （P〈0.01）, compared with the quiet control group using the same dosage, the low, moderate and high dosage training exposed ones were significantly increased （P〈0.05）, moreover, there was an enhancing trend of increasing ANP concentration in the moderate and high groups than in the low one. Conclusion Aerobic endurance training may eliminates the negative effects of NP exposed which could affect ANP level of rat＇ s heart, and obviously recover ANP level under the states of the moderate and high dosage exposed.

关 键 词：壬基酚 心钠素 有氧耐力训练 

分 类 号：R994.6[医药卫生—毒理学]