肠道病毒71感染后脑干损害与神经源性肺水肿相关性研究  

Brain stem damage after enterovirus 71 infection and neurogenic pulmonary edema

作　　者：张宏伟[1] 陈欣[1] 李姣[1] 

机构地区：[1]天津市儿童医院,天津300074

出　　处：《现代中西医结合杂志》2009年第16期1845-1846,1848,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的了解肠道病毒71(EV71)感染后脑干损害与神经源性肺水肿的相关性,探讨相应治疗方案。方法回顾性分析本院2008年7—11月收治的18例EV71感染后脑干损害病例的相关临床资料。结果18例患儿中8例(44%)发生神经源性肺水肿。早期应用呋塞米及甘露醇脱水,给予人免疫球蛋白、肾上腺皮质激素治疗;对发生神经源性肺水肿者行气管插管呼吸机机械通气治疗,并予磷酸二酯酶抑制剂。16例救治成功,预后良好;1例肺水肿症状改善,住院7 d放弃治疗;1例死亡。结论EV71感染后脑干损害与神经源性肺水肿的发生有密切相关性,早期发现并及时治疗是降低病死率的关键。Objective It is to understand the relation between brain stem damage after enterovirus 71（EV71） infection and neurogenic pulmonary edema in order to explore the therapeutic schedule. Methods The clinical data of 18 cases of brain stem damage after EV71 infection in this hospital from July to November 2008 was retrospectively analyzed. Results There were 8 cases with Neurogenic pulmonary edema in the children patients. In the early stage, dehydration treatment was applied using furosemide and mannitol, pulse treatment was applied using human immunoglobutin and adrenal cortical hormone. For those with neurogenic pulmonary edema, tracheal intubation respirator was used for mechanical ventilation and phosphodiesterase inhibitor treatment was applied. 16 cases were successfully cured with good prognosis, 1 case saw improved pulmonary edema condition and treatment was abandoned after 7 days of hospitalization, 1 patient died. Conclusion Brain stem damage after EV71 infection has close relativity with the occurrence of neurogenic pulmonary edema. Early discovery and timely treatment is the key to reducing case fatality.

关 键 词：肠道病毒71 脑干脑炎 神经源性肺水肿 

分 类 号：R512.5[医药卫生—内科学]