老年人血压正常高值的昼夜节律变化与靶器官损害的相关性研究  

The relationship between circadian rhythm and target-organ damage in blood pressure high-normal people

作　　者：张省亮[1] 谈世进[1] 夏瑾玮[1] 

机构地区：[1]上海交通大学附属第六人民医院老年病科,上海200233

出　　处：《蚌埠医学院学报》2009年第5期414-416,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨老年血压正常高值者血压昼夜节律变化与靶器官损害之间的关系。方法:入选正常高值血压受试者86例,根据24 h动态血压结果分成杓型组55例和非杓型组31例,分别测定两组的尿微量白蛋白(mAlb)、颈动脉内膜中层厚度(IMT)和左心室重量指数(LVMI),并对两组数据进行比较。结果:非杓型组的mAlb、IMT及LVMI均明显高于杓型组(P<0.01和P<0.05)。结论:血压昼夜节律改变与老年正常高值血压者早期靶器官损害有关。Objective ：To investigate the relationship between circadian rhythm and target-organ damage in the elderly with blood pressure high-normal. Methods ：Twenty-four hours ambulatory blood pressure monitoring profiles were recorded in all subjects. According to the results of ambulatory blood pressure monitoring,86 subjects with blood pressure high-normal were divided into two groups：normal circadian rhythm group（ n =55） and abnormal circadian rhythm group（ n = 31 ）. Urinary microalbuminufia（mAlb） was determined by radioimmunoassay and intima-media thickness of carotid artery （IMT） was measured by high resolution colour Doppler ultrasonography. All the subjects were performed ultrasonic cardiography. The left ventricular mass index （ LVMI ） was calculated according to the Devereux formula. Results： The abnormal circadian rhythm group had higher mAlb, IMT and LVMI than the normal circadian rhythm group （ P 〈 0. 01 and P 〈 0. 05 ）. Condusions：Abnormal circadian rhythm of blood pressure indicates the possibility of more severe target-organ damage in the elderly withhigh-normal blood pressure.

关 键 词：血压测定 老年病学 血压正常高值 昼夜节律 靶器官损害 

分 类 号：R443.5[医药卫生—诊断学]