心复康口服液对心梗后心衰大鼠心肌三磷酸腺苷含量的影响  

Effect of XinFuKang Oral Liquid on the Content of ATP in Cardiac Tissue of Heart Failure Rats after Myocardial Infarction

作　　者：胡元会[1] 吴华芹[1] 马铁民[2] 陈双厚[1] 刘瑞华[1] 张百舜[1] 程慧平[1] 褚瑜光[1] 房玉涛[1] 石洁[1] 何建成[3] 曹雪滨[4] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京大学医学部基础医学院,北京100029 [3]上海中医药大学基础医学院,上海201203 [4]中国人民解放军二五二医院,河北保定071000

出　　处：《时珍国医国药》2009年第5期1029-1030,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30271619);北京市自然科学基金(No.7042054)

摘　　要：目的观察心复康口服液对心梗后心衰大鼠梗塞周围心肌中三磷酸腺苷(ATP)含量的影响。方法采用结扎SD大鼠左冠状动脉前降支致心梗后心衰大鼠模型,用心复康口服液于术后24 h灌胃给药,以卡托普利作为阳性对照药。给药2,4,6,8周,观察大鼠梗死周围心肌ATP含量。结果与模型组比较,心复康口服液和卡托普利组皆明显增加梗死周围心肌中ATP含量(P<0.01)。结论心复康口服液可升高梗死周围心肌组织中ATP含量从而改善心梗后心衰大鼠心肌能量代谢。Objeetive To observe the effect of Xinfukang（XFK） Oral Liquid on the content of ATP in cardiac tissue of heart failure myocardial infarction. Methods The AMI model was established by ligating left anterial descending eoronary artery . 24 h later, the rats were fed XFK Oral Liquid by oral garage. Captopril served as control. After 2,4,6,8 weeks treatment, the content of ATP was determined. Results Compared with model group, the content of ATP was obviously increased in XFK Oral Liquid group and captopril group（P 〈 0.01 ）. Conclusion XFK Oral Liquid can inhibit the obstacle of energy metabolism by increasing the content of ATP.

关 键 词：心复康口服液 高能磷酸化合物 心力衰竭 大鼠 

分 类 号：R285.5[医药卫生—中药学]